Mathematical modeling and simulation in animal health–Part II: Principles, methods, applications, and value of physiologically based pharmacokinetic modeling in …

Z Lin, R Gehring, JP Mochel, T Lave… - Journal of veterinary …, 2016 - Wiley Online Library
This review provides a tutorial for individuals interested in quantitative veterinary
pharmacology and toxicology and offers a basis for establishing guidelines for …

Rational pharmacotherapy in infectious diseases: issues related to drug residues in edible animal tissues

L Canton, C Lanusse, L Moreno - Animals, 2021 - mdpi.com
Simple Summary Drug use is essential to treat diseases in food-producing animals. The
most widely used drugs are antiparasitics and antimicrobials. They contribute to …

Comparison of pharmacokinetics and milk elimination of flunixin in healthy cows and cows with mastitis

LW Kissell, TL Leavens, RE Baynes… - Journal of the …, 2015 - Am Vet Med Assoc
Objective—To determine whether pharmacokinetics and milk elimination of flunixin and 5-
hydroxy flunixin differed between healthy and mastitic cows. Design—Prospective controlled …

Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos taurus)

TL Leavens, LA Tell, LW Kissell, GW Smith… - Food Additives & …, 2014 - Taylor & Francis
Frequent violation of flunixin residues in tissues from cattle has been attributed to non-
compliance with the USFDA-approved route of administration and withdrawal time …

Integration of Food Animal Residue Avoidance Databank (FARAD) empirical methods for drug withdrawal interval determination with a mechanistic population-based …

M Li, YH Cheng, JT Chittenden, RE Baynes, LA Tell… - Archives of …, 2019 - Springer
Violative chemical residues in animal-derived food products affect food safety globally and
have impact on the trade of international agricultural products. The Food Animal Residue …

[HTML][HTML] Plasma pharmacokinetics and milk residues of flunixin and 5-hydroxy flunixin following different routes of administration in dairy cattle

LW Kissell, GW Smith, TL Leavens, RE Baynes… - Journal of dairy …, 2012 - Elsevier
The objective of this study was to determine if the plasma pharmacokinetics and milk
elimination of flunixin (FLU) and 5-hydroxy flunixin (5OH) differ following intramuscular and …

Development of a Physiologically Based Pharmacokinetic Model for Flunixin in Cattle and Swine Following Dermal Exposure

X Wu, Q Chen, WC Chou, FP Maunsell… - Toxicological …, 2024 - academic.oup.com
Flunixin meglumine is a nonsteroidal anti-inflammatory drug (NSAID). Banamine®
Transdermal is a pour-on formulation of flunixin approved for pain control in beef and dairy …

A framework for meta-analysis of veterinary drug pharmacokinetic data using mixed effect modeling

M Li, R Gehring, Z Lin, J Riviere - Journal of Pharmaceutical Sciences, 2015 - Elsevier
Combining data from available studies is a useful approach to interpret the overwhelming
amount of data generated in medical research from multiple studies. Paradoxically, in …

Pharmacokinetic Parameters and Estimated Milk Withdrawal Intervals for Domestic Goats (Capra Aegagrus Hircus) After Administration of Single and Multiple …

JS Smith, TL Marmulak, JA Angelos, Z Lin… - Frontiers in Veterinary …, 2020 - frontiersin.org
Introduction: The study objectives were to estimate plasma flunixin (FLU) pharmacokinetic
parameters and milk depletion profiles for FLU and its metabolite (5-hydroxy flunixin; 5-OH) …

Interspecies mixed-effect pharmacokinetic modeling of penicillin G in cattle and swine

M Li, R Gehring, L Tell, R Baynes… - Antimicrobial Agents …, 2014 - Am Soc Microbiol
Extralabel drug use of penicillin G in food-producing animals may cause an excess of
residues in tissue which will have the potential to damage human health. Of all the …