[HTML][HTML] New insight into molecular mechanism of P450-Catalyzed metabolism of emerging contaminants and its consequence for human health: A case study of …

Y Gao, X Hu, C Deng, M Wang, X Niu, N Luo, Y Ji… - Environment …, 2023 - Elsevier
Hydroxylated metabolites in the living body are considered as a potential biomarker of
exposure to emerging contaminations (ECs) and breast cancer, but their formation …

New insights into enhanced biodegradation of 4-bromphenol in a nitrate-reducing system: Process performance and mechanism

J Wang, Q Chi, L Pan, R Zhang, Y Mu, J Shen - Water Research, 2023 - Elsevier
Due to the recalcitrant nature of halogenated phenol, conventional anaerobic bioprocess is
often limited by low removal efficiency and poor process stability. At the presence of electron …

Mechanistic aspects of reactive metabolite formation in clomethiazole catalyzed biotransformation by cytochrome P450 enzymes

EM Kamel, AM Tawfeek, AA El-Bassuony… - Organic & …, 2023 - pubs.rsc.org
Clomethiazole (CLM), a sedative and anticonvulsant drug, is commonly employed for the
treatment of alcohol withdrawal syndrome because it suppresses cytochrome P450 (P450) …

Cometabolic biodegradation system employed subculturing photosynthetic bacteria: a new degradation pathway of 4-chlorophenol in hypersaline wastewater

L Wang, Z Hu, M Hu, J Zhao, P Zhou, Y Zhang… - Bioresource …, 2022 - Elsevier
chlorophenol (4-CP) as a toxic persistent pollutant is quite difficult treatment by using
traditional biological processes. Herein, photosynthetic bacteria (PSB) driven cometabolic …

Functionality, characterization and DEGs contribution by engineering isolate Pseudomonas P1 to elucidate the regulation mechanisms of p-chlorophenol-4 …

S Sun, Y Wang, S Chen, Z Li, C Zhao, Q Liu… - Chemical Engineering …, 2023 - Elsevier
Engineered bacteria are one of the greenest and most profitable biodegradation methods for
removing noxious chlorophenols and chloramines from the environment. This study aims to …

Enantioselective metabolism of novel chiral insecticide Paichongding by human cytochrome P450 3A4: A computational insight

G Ma, Q Wang, K Ma, Y Chen, J Lu, J Zhang… - Environmental …, 2023 - Elsevier
As a novel chiral neonicotinoid insecticide, Paichongding (IPP) has been widely applied in
agriculture due to its excellent insecticidal activity. However, the enantioselective …

[HTML][HTML] Tolerance Mechanisms and Removal Efficiency of Chlorella pyrenoidosa in Treating 3-Fluorophenol Pollution

M Li, Z Shang, Y Ma, H Zhao, Z Ni, Z Wei, X Zhang - Metabolites, 2024 - mdpi.com
This study investigates the growth tolerance mechanisms of Chlorella pyrenoidosa to 3-
fluorophenol and its removal efficiency by algal cells. Our results indicate that C …

Computational insight into biotransformation profiles of organophosphorus flame retardants to their diester metabolites by cytochrome P450

Y Jia, T Yao, G Ma, Q Xu, X Zhao, H Ding, X Wei, H Yu… - Molecules, 2022 - mdpi.com
Biotransformation of organophosphorus flame retardants (OPFRs) mediated by cytochrome
P450 enzymes (CYPs) has a potential correlation with their toxicological effects on humans …

1-Nitropyrene Metabolism and Health Risk: Identification of Key Enzymes, Pathways, and Metabolites Using a Multimethod Approach

M Wang, Y Gao, N Luo, G Chen, X Niu, G Li… - Environment & …, 2023 - ACS Publications
Polycyclic aromatic hydrocarbon (PAH) derivatives have a widespread presence in the
environment and even the human body, but their metabolism and potential risk remain …

Biotransformation of BPA via epoxidation catalyzed by Cytochrome P450

R Yadav, N Awasthi, D Kumar - Inorganic Chemistry Communications, 2022 - Elsevier
Metabolites formed during the biotransformation mediated by CYP450 may turn toxic.
Investigations upon the mechanism involved in the formation of such toxic byproducts are …