Increasing evidence suggests that renal inflammation contributes to the pathogenesis and
progression of diabetic kidney disease (DKD) and that anti-inflammatory therapies might …

The recognition of microbial or danger-associated molecular patterns by complement
proteins initiates a cascade of events that culminates in the activation of surface complement …

The complement system plays a key role in pathogen immunosurveillance and tissue
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …

The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …

Endometriosis (EM) is a chronic disease characterized by the presence and proliferation of
functional endometrial glands and stroma outside the uterine cavity. Ovaries and pelvic …

The complement system is well known for its role in innate immunity and in maintenance of
tissue homeostasis, providing a first line of defence against infection and playing a key role …

Despite the growing recognition of the complement system as a major contributor to a variety
of clinical conditions, the therapeutic arsenal has remained scarce. The introduction of an …

Within a short few years, the number of complement inhibitors that are either approved for
therapeutic application or evaluated in late‐stage clinical trials has expanded remarkably …

Dysregulation of the complement system underlies the pathophysiology of many diseases.
Renewed interest in complement occurred with the recognition that its therapeutic inhibition …