Tumor necrosis factor‐(TNF‐) like weak inducer of apoptosis (TWEAK) participates in
multiple biological activities via binding to its sole receptor—fibroblast growth factor …

TNF and IL-17 are two cytokines that drive dysregulated keratinocyte activity, and their
targeting is highly efficacious in patients with psoriasis, but whether these molecules act with …

Psoriasis, an immune‐mediated chronic inflammatory skin disease, imposes a huge mental
and physical burden on patients and severely affects their quality of life. Punicalagin (PU) …

As a multifunctional cytokine, lipocalin 2 is weakly expressed in skin and serum under
normal conditions. However, it is over-expressed by neutrophils and keratinocytes in the …

TRAF2 is a component of TNF superfamily signalling complexes and plays an essential role
in the regulation and homeostasis of immune cells. TRAF2 deficient mice die around birth …

Skin psoriasis is defined as receiving external stimulation to activate skin dendritic cells
(DCs) which can release interleukin 23 (IL-23) to interlink the innate and adaptive immunity …

Atopic dermatitis (AD) and psoriasis are driven by alternate type 2 and type 17 immune
responses, but some proteins might be critical to both diseases. Here we show that a …

Background Adoptive cell therapy has achieved great success in treating hematological
malignancies. However, the production of chimeric antigen receptor T (CAR-T) cell therapy …

Psoriasis is a chronic, relapsing inflammatory skin disease. The pathogenesis of psoriasis is
complex and has not been fully understood. C10orf99 was a recently identified human …

Poly-(ADP)-ribose polymerase inhibitors (PARPi) and platinum-based drugs are promising
therapies for triple negative breast cancers (TNBC) with BRCA1 or BRCA2 loss. PARPi (s) …