Improved DNA vaccine delivery with needle-free injection systems

C Ledesma-Feliciano, R Chapman, JW Hooper… - Vaccines, 2023 - mdpi.com
DNA vaccines have inherent advantages compared to other vaccine types, including safety,
rapid design and construction, ease and speed to manufacture, and thermostability …

Vaccination into the dermal compartment: techniques, challenges, and prospects

J Hettinga, R Carlisle - Vaccines, 2020 - mdpi.com
In 2019, an 'influenza pandemic'and 'vaccine hesitancy'were listed as two of the top 10
challenges to global health by the WHO. The skin is a unique vaccination site, due to its …

Immunogenicity of candidate MERS-CoV DNA vaccines based on the spike protein

SS Al-Amri, AT Abbas, LA Siddiq, A Alghamdi… - Scientific reports, 2017 - nature.com
MERS-coronavirus is a novel zoonotic pathogen which spread rapidly to> 25 countries since
2012. Its apparent endemicity and the wide spread of its reservoir host (dromedary camels) …

Mumps outbreaks in vaccinated populations—is it time to re-assess the clinical efficacy of vaccines?

AR Connell, J Connell, TR Leahy… - Frontiers in immunology, 2020 - frontiersin.org
History illustrates the remarkable public health impact of mass vaccination, by dramatically
improving life expectancy and reducing the burden of infectious diseases and co-morbidities …

HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge

AT Jones, X Shen, KL Walter, CC LaBranche… - Nature …, 2019 - nature.com
The oral mucosa is an attractive site for mucosal vaccination, however the thick squamous
epithelium limits antigen uptake. Here we utilize a modified needle-free injector to deliver …

Synthetic SARS-CoV-2 spike-based DNA vaccine elicits robust and long-lasting th1 humoral and cellular immunity in mice

SS Alamri, KA Alluhaybi, RY Alhabbab… - Frontiers in …, 2021 - frontiersin.org
The ongoing global pandemic of coronavirus disease 2019 (COVID-19) calls for an urgent
development of effective and safe prophylactic and therapeutic measures. The spike (S) …

Characterization of jets for impulsively-started needle-free jet injectors: Influence of fluid properties

P Rohilla, YS Rane, I Lawal, A Le Blanc, J Davis… - Journal of Drug Delivery …, 2019 - Elsevier
An experimental study was performed to assess the hydrodynamics of liquid jets used for
needle-free injection, where the typical orifice diameter is~ 155 μm and velocity is in range …

The potential role of using vaccine patches to induce immunity: platform and pathways to innovation and commercialization

K Badizadegan, JL Goodson, PA Rota… - Expert review of …, 2020 - Taylor & Francis
Introduction: In the last two decades, the evidence related to using vaccine patches with
multiple short projections (≤ 1 mm) to deliver vaccines through the skin increased …

Immunogenicity, duration of protection, effectiveness and safety of rubella containing vaccines: A systematic literature review and meta-analysis

J Van den Boogaard, B de Gier, POB Lima, S Desai… - Vaccine, 2021 - Elsevier
Background Rubella containing vaccines (RCV) prevent rubella virus infection and
subsequent congenital rubella syndrome (CRS). To update the evidence on …

[HTML][HTML] Clinical study of safety and immunogenicity of pentavalent DTP-HB-Hib vaccine administered by disposable-syringe jet injector in India

A Bavdekar, N Malshe, L Ravichandran, A Sapru… - Contemporary clinical …, 2019 - Elsevier
Introduction We conducted a randomized, observer-blind, non-inferiority, parallel-group
clinical study of diphtheria, tetanus, pertussis, hepatitis B, and Haemophilus influenzae type …