New advances in synthetic methodologies that allow rapid access to a wide variety of
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …

Sequential, domino and tandem reactions could be defined as a sequence of synthetic
transformations that occur one after the other, in the same reaction flask. This Review …

An analysis of chemical reactions used in current medicinal chemistry (2014), three decades
ago (1984), and in natural product total synthesis has been conducted. The analysis …

Herein, we report an achiral dirhodium complex and chiral phosphoric acid cooperatively
catalyzed asymmetric three-component reaction of enynal with alcohol and imine, affording …

The current method represents an electrochemically driven synthetic route to access
polysubstituted selenofuran derivatives through the diselenide-promoted cyclization of …

Kappa opioid receptor (KOR) is a member of the opioid receptor system, the G protein-
coupled receptors that are expressed throughout the peripheral and central nervous …

Pain remains a very pervasive problem throughout medicine. Classical pain management is
achieved through the use of opiates belonging to the mu opioid receptor (MOR) class, which …

Vitex agnus‐castus L.(Lamiaceae) is a medicinal plant historically used throughout the
Mediterranean region to treat menstrual cycle disorders, and is still used today as a clinically …

This paper is the thirty-seventh consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2014 …

All possible diastereomeric C9-hydroxymethyl-, hydroxyethyl-, and hydroxypropyl-
substituted 5-phenylmorphans were synthesized to explore the three-dimensional space …