The growing interest for comparing protein internal dynamics owes much to the realisation
that protein function can be accompanied or assisted by structural fluctuations and …

Advances in sequencing techniques and statistical methods have made it possible not only
to predict sequences of ancestral proteins but also to identify thousands of mutations in the …

Abstract The interface of protein structural biology, protein biophysics, molecular evolution,
and molecular population genetics forms the foundations for a mechanistic understanding of …

β-lactamases are produced by many modern bacteria as a mechanism of resistance toward
β-lactam antibiotics, the most common antibiotics in use. β-lactamases, however, are ancient …

Protein structures are valuable tools for understanding protein function. However, protein
dynamics is also considered a key element in protein function. Therefore, in addition to …

Motivation: The function of a protein depends not only on its structure but also on its
dynamics. This is at the basis of a large body of experimental and theoretical work on protein …

Protein structure is dynamic: the intrinsic flexibility of polypeptides facilitates a range of
conformational fluctuations, and individual protein chains can assemble into complexes …

Rad6, an E2 ubiquitin-conjugating enzyme conserved from yeast to humans, functions in
transcription, genome maintenance, and proteostasis. The contributions of many conserved …

Recent studies have drawn attention to the evolution of protein dynamics, in addition to
sequence and structure, based on the premise structure-encodes-dynamics-encodes …

Introduction Evolution and design of protein complexes are frequently viewed through the
lens of amino acid mutations at protein interfaces, but we showed previously that residues …