Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic
characteristics of cancer stem cells, with several studies indicating that they are mainly …

Cancer cells exhibit slightly elevated levels of reactive oxygen species (ROS) compared with
normal cells, and approximately 90% of intracellular ROS is produced in mitochondria. In …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Significance: Mitochondrial function is central to a wide range of biological processes in
health and disease and there is considerable interest in developing small molecules that are …

Mitochondria have emerged as an intriguing target for anti-cancer drugs, inherent to vast
majority if not all types of tumours. Drugs that target mitochondria and exert anti-cancer …

Lung cancer is the leading cause of cancer-related death in humans and the multidrug
resistance (MDR) is the major obstacle to successful chemotherapy of lung cancer. In this …

In the last few decades, the role of cancer stem cells in initiating tumors, metastasis,
invasion, and resistance to therapies has been recognized as a potential target for tumor …

Over the past 30 years the mitochondrial permeability transition–the permeabilization of the
inner mitochondrial membrane due to the opening of a wide pore–has progressed from …

Cancer stem cells (CSCs) are believed as the initiators of the occurrence, development and
recurrence of malignant tumors. Targeting this unique cell population would provide a less …