Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications

K Venkatesh, SK Ghosh, M Mullick… - Cell and tissue …, 2019 - Springer
Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a
prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites …

Stem cell therapy for spinal cord injury

L Huang, C Fu, F Xiong, C He, Q Wei - Cell transplantation, 2021 - journals.sagepub.com
Traumatic spinal cord injury (SCI) results in direct and indirect damage to neural tissues,
which results in motor and sensory dysfunction, dystonia, and pathological reflex that …

Clinical translation of stem cell therapy for spinal cord injury still premature: results from a single-arm meta-analysis based on 62 clinical trials

Z Shang, M Wang, B Zhang, X Wang, P Wanyan - BMC medicine, 2022 - Springer
Background How much scientific evidence is there to show that stem cell therapy is sufficient
in preclinical and clinical studies of spinal cord injury before it is translated into clinical …

Current options for cell therapy in spinal cord injury

I Vismara, S Papa, F Rossi, G Forloni… - Trends in molecular …, 2017 - cell.com
Spinal cord injury (SCI) is a complex pathology that evolves after primary acute mechanical
injury, causing further damage to the spinal cord tissue that exacerbates clinical outcomes …

Cell therapies for spinal cord injury: a review of the clinical trials and cell-type therapeutic potential

BF Ribeiro, BC da Cruz, BM de Sousa, PD Correia… - Brain, 2023 - academic.oup.com
Spinal cord injury (SCI) is an as yet untreatable neuropathology that causes severe
dysfunction and disability. Cell-based therapies hold neuroregenerative and neuroprotective …

[HTML][HTML] Clinical neurorestorative therapeutic guidelines for spinal cord injury (IANR/CANR version 2019)

H Huang, W Young, S Skaper, L Chen… - Journal of orthopaedic …, 2020 - Elsevier
Functional restoration after spinal cord injury (SCI) is one of the most challenging tasks in
neurological clinical practice. With a view to exploring effective neurorestorative methods in …

Biomaterial-supported cell transplantation treatments for spinal cord injury: challenges and perspectives

S Liu, T Schackel, N Weidner… - Frontiers in cellular …, 2018 - frontiersin.org
Spinal cord injury (SCI), resulting in para-and tetraplegia caused by the partial or complete
disruption of descending motor and ascending sensory neurons, represents a complex …

Mesenchymal stem cell-based therapy as a new therapeutic approach for acute inflammation

K Abdolmohammadi, T Mahmoudi, M Alimohammadi… - Life Sciences, 2023 - Elsevier
Acute inflammatory diseases such as acute colitis, kidney injury, liver failure, lung injury,
myocardial infarction, pancreatitis, septic shock, and spinal cord injury are significant causes …

Advancing spinal cord injury treatment through stem cell therapy: A comprehensive review of cell types, challenges, and emerging technologies in regenerative …

CW Zeng - International journal of molecular sciences, 2023 - mdpi.com
Spinal cord injuries (SCIs) can lead to significant neurological deficits and lifelong disability,
with far-reaching physical, psychological, and economic consequences for affected …

Combining cell therapy with human autologous Schwann cell and bone marrow-derived mesenchymal stem cell in patients with subacute complete spinal cord injury …

S Oraee-Yazdani, M Akhlaghpasand… - Stem Cell Research & …, 2021 - Springer
Background Cellular transplantations have promising effects on treating spinal cord injury
(SCI) patients. Mesenchymal stem cells (MSCs) and Schwann cells (SCs), which have safety …