Proteolysis-targeting chimeras (PROTACs) and related molecules that induce targeted
protein degradation by the ubiquitin–proteasome system represent a new therapeutic …

In this review, we describe the role of suppressor of cytokine signaling-3 (SOCS3) in
modulating the outcome of infections and autoimmune diseases as well as the underlying …

Suppressor of cytokine signalling (SOCS) proteins are inhibitors of cytokine signalling
pathways. Studies have shown that SOCS proteins are key physiological regulators of both …

The inhibitory protein SOCS3 plays a key part in the immune and hematopoietic systems by
regulating signaling induced by specific cytokines. SOCS3 functions by inhibiting the …

IL-6 a multi-functional cytokine with important effects in both inflammation and
haematopoiesis. SOCS3 is the primary inhibitor of IL-6 signalling, interacting with gp130, the …

Covalent attachment of ubiquitin-like proteins (Ubls) is a predominant mechanism for
regulating protein function in eukaryotes. Several structurally related Ubls, such as ubiquitin …

The discovery of the Suppressor of Cytokine Signaling (SOCS) family of proteins has
resulted in a significant body of research dedicated to dissecting their biological functions …

Src homology 2 (SH2) domains are the largest family of interaction modules encoded by the
human genome to recognize tyrosine-phosphorylated sequences and thereby play pivotal …

The mounting of an effective immune response requires the coordinated function of both the
innate and the adaptive arm of the immune system. Cells from both types of immunity …

Suppressors of cytokine signaling 3 (SOCS3) has been shown to be an important and non-
redundant feedback inhibitor of several cytokines including leukemia inhibitory factor, IL-6 …