Microbiome engineering for sustainable agriculture: using synthetic biology to enhance nitrogen metabolism in plant-associated microbes

SW Han, Y Yoshikuni - Current Opinion in Microbiology, 2022 - Elsevier
Highlights•Plant–microbe interactions are central to sustainable agriculture.•Nitrogen
metabolites play essential roles in plant-growth promotion.•Pyridoxal-5′-phosphate …

Aromatic L-amino acid decarboxylases: mechanistic features and microbial applications

SW Han, JS Shin - Applied Microbiology and Biotechnology, 2022 - Springer
Aromatic L-amino acid decarboxylases (AADCs) catalyze the conversion of aromatic L-
amino acids into aromatic monoamines that play diverse physiological and biosynthetic …

γ-Polyglutamic Acid Production, Biocontrol, and Stress Tolerance: Multifunction of Bacillus subtilis A-5 and the Complete Genome Analysis

N Bai, Y He, H Zhang, X Zheng, R Zeng, Y Li… - International Journal of …, 2022 - mdpi.com
Bacillus subtilis A-5 has the capabilities of high-molecular-weight γ-PGA production,
antagonism to plant pathogenic fungi, and salt/alkaline tolerance. This multifunctional …

Construction of cell factory capable of efficiently converting l-tryptophan into 5-hydroxytryptamine

Y Wang, X Chen, Q Chen, N Zhou, X Wang… - Microbial Cell …, 2022 - Springer
Abstract Background l-Tryptophan (l-Trp) derivatives such as 5-hydroxytryptophan (5-HTP)
and 5-hydroxytryptamine (5-HT), N-Acetyl-5-hydroxytryptamine and melatonin are important …

[HTML][HTML] Identification of metabolites produced by six gut commensal Bacteroidales strains using non-targeted LC-MS/MS metabolite profiling

MV Fernandez-Cantos, AF Babu, K Hanhineva… - Microbiological …, 2024 - Elsevier
As the most abundant gram-negative bacterial order in the gastrointestinal tract,
Bacteroidales bacteria have been extensively studied for their contribution to various …

[HTML][HTML] Ability of Latilactobacillus curvatus FAM25164 to produce tryptamine: Identification of a novel tryptophan decarboxylase

S Irmler, T Bavan, E Binz, R Portmann - Food Microbiology, 2023 - Elsevier
Screenings of cheese isolates revealed that the Latilactobacillus curvatus strain FAM25164
formed tryptamine and tyramine. In the present study, it was studied whether a tryptophan …

Fermentative Production of Halogenated Tryptophan Derivatives with Corynebacterium glutamicum Overexpressing Tryptophanase or Decarboxylase Genes

A Kerbs, A Burgardt, KH Veldmann, T Schäffer… - …, 2022 - Wiley Online Library
The aromatic amino acid l‐tryptophan serves as a precursor for many valuable compounds
such as neuromodulators, indoleamines and indole alkaloids. In this work, tryptophan …

One-pot biosynthesis of aromatic D-amino acids and neuroactive monoamines via enantioselective decarboxylation under in situ product removal using ion exchange …

SW Han, Y Choi, Y Jang, JS Kim, JS Shin - Biochemical Engineering …, 2022 - Elsevier
Living organisms have evolved a myriad number of enzymes, which inspires reaction
engineers to reroute native biocatalytic utility into scalable synthetic purposes. One of such …

In-vitro digestion models to examine the effects of Plant-Based Meat substitutes on Gut Microbial Metabolites

D Izquierdo-Sandoval, X Duan, C Fryganas, T Portoles… - bioRxiv, 2023 - biorxiv.org
The increasing popularity of plant-based meat alternatives (PBMAs) has triggered a
contentious debate about their impact on gut health in comparison to traditional animal …

Exploring the mechanism of compromised thermostability of aromatic L-amino acid decarboxylase from Bacillus atrophaeus through comparative molecular dynamics …

H Zhang, Y Cheng, Q Ge, J Yu, G Fu, Y Gao… - Computational and …, 2023 - Elsevier
As an excellent biocatalyst, aromatic l-amino acid decarboxylase from Bacillus atrophaeus
(BaAADC) catalyzes the production of various vital aromatic biogenic amines. However, its …