Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …

The phosphoinositide 3-kinase (PI3K) pathway plays an integral role in many cellular
processes and is frequently altered in cancer, contributing to tumor growth and survival …

Background Treatment options for women presenting with triple negative breast cancer
(TNBC) are limited due to the lack of a therapeutic target and as a result, are managed with …

Kinase inhibitors have limited success in cancer treatment because tumors circumvent their
action. Using a quantitative proteomics approach, we assessed kinome activity in response …

Triple‐negative breast cancer (TNBC) is a heterogeneous disease with distinct molecular
subtypes that respond differentially to chemotherapy and targeted agents. The absence of …

Crosstalk and complexity within signaling pathways and their perturbation by oncogenes
limit component-by-component approaches to understanding human disease. Network …

Cysteine sulfinic acid or S-sulfinylation is an oxidative post-translational modification
(OxiPTM) that is known to be involved in redox-dependent regulation of protein function but …

Despite all of the progress in understanding its molecular biology and pathogenesis,
glioblastoma (GBM) is one of the most aggressive types of cancers, and without an efficient …

The Bliss independence model is widely used to analyze drug combination data when
screening for candidate drug combinations. The method compares the observed …

Cell-surface receptors frequently use scaffold proteins to recruit cytoplasmic targets, but the
rationale for this is uncertain. Activated receptor tyrosine kinases, for example, engage …