Cellular, metabolic, and developmental dimensions of whole-body regeneration in Hydra

MC Vogg, W Buzgariu… - Cold Spring Harbor …, 2021 - cshperspectives.cshlp.org
Here we discuss the developmental and homeostatic conditions necessary for Hydra
regeneration. Hydra is characterized by populations of adult stem cells paused in the G2 …

Knock down to level up: Reframing RNAi for invertebrate ecophysiology

JE Lebenzon, J Toxopeus - … Biochemistry and Physiology Part A: Molecular …, 2024 - Elsevier
Comparative ecophysiologists strive to understand physiological problems in non-model
organisms, but molecular tools such as RNA interference (RNAi) are under-used in our field …

The Wnt/β-catenin/TCF/Sp5/Zic4 Gene Network That Regulates Head Organizer Activity in Hydra Is Differentially Regulated in Epidermis and Gastrodermis

L Iglesias Ollé, C Perruchoud, PGL Sanchez, MC Vogg… - Biomedicines, 2024 - mdpi.com
Hydra head formation depends on an organizing center in which Wnt/β-catenin signaling,
that plays an inductive role, positively regulates Sp5 and Zic4, with Sp5 limiting Wnt3/β …

circSSPO boosts growth of esophageal squamous cell carcinoma through upregulation of micrRNA-6820-5p-mediated KLK8 and PKD1 expression

Q Luo, J Li, H Miao, S Su, Y Chen, C Xu, C Zhao… - Cell Biology and …, 2023 - Springer
Investigation on a competitive endogenous RNA (ceRNA) network attracted lots of attention
due its function in cancer regulation. Here, we probed into the possible molecular …

Apical-to-basal graded ROS metabolism in intact Hydra leads to distinct levels of injury-induced ROS signaling in apical and basal regenerating tips

N Suknovic, S Reiter-Karam, O Chara, W Buzgariu… - bioRxiv, 2022 - biorxiv.org
After mid-gastric bisection, Hydra regenerates a head from the lower half and a basal disc
from the upper one. What signals elicit two distinct regenerative responses in bisected Hydra …