The potential roles of breast cancer stem cells (BCSCs) in tumor initiation and recurrence
have been recognized for many decades. Due to their strong capacity for self-renewal and …

Solid tumors often grow in a micro-environment characterized by< 2% O 2 tension. This
condition, together with the aberrant activation of specific oncogenic patwhays, increases …

A variety of Poly (ADP-ribose) polymerase inhibitors (PARPi) have been approved for the
clinical treatment of breast cancers. However, pre-clinical and clinical evidences indicate …

Cancer-associated fibroblasts (CAF) are a major cell type in the stroma of solid tumors and
can exert both tumor-promoting and tumor-restraining functions. CAF heterogeneity is …

Hypoxia is a characteristic of tumor microenvironment (TME) and is a major contributor to
tumor progression. Yet, subtype identification of tumor-associated non-malignant cells at …

Background: Increasing evidence showed that the clinical significance of the interaction
between hypoxia and immune status in tumor microenvironment. However, reliable …

Background Stromal components of the tumor microenvironment contribute to bladder
cancer progression, and Cancer-Associated Fibroblasts (CAFs) were reported to play an …

More than a decade ago IL-1 blockade was suggested as an add-on therapy for the
treatment of cancer. This proposal was based on the overall safety record of anti-IL-1 …

Simple Summary The tumoral microenvironment comprises cancer cells and surrounding
components, including immune and endothelial cells, along with the extracellular matrix. As …

Scoring of tumor-infiltrating lymphocytes (TILs) in breast cancer specimens has gained
increasing attention, as TILs have prognostic and predictive value in HER2+ and triple …