Histone deacetylases in cardiac fibrosis: current perspectives for therapy
H Tao, KH Shi, JJ Yang, C Huang, HY Zhan, J Li - Cellular signalling, 2014 - Elsevier
Cardiac fibrosis is an important pathological feature of cardiac remodeling in heart diseases.
The molecular mechanisms of cardiac fibrosis are unknown. Histone deacetylases (HDACs) …
The molecular mechanisms of cardiac fibrosis are unknown. Histone deacetylases (HDACs) …
Identification of potential isoform-selective histone deacetylase inhibitors for cancer therapy: A combined approach of structure-based virtual screening, ADMET …
Histone deacetylases (HDACs) have gained increased attention as targets for anticancer
drug design and development. HDAC inhibitors have proven to be effective for reversing the …
drug design and development. HDAC inhibitors have proven to be effective for reversing the …
Searching the conformational complexity and binding properties of HDAC6 through docking and molecular dynamic simulations
Y Sixto-López, M Bello… - Journal of …, 2017 - Taylor & Francis
Histone deacetylases (HDACs) are a family of proteins involved in the deacetylation of
histones and other non-histones substrates. HDAC6 belongs to class II and shares similar …
histones and other non-histones substrates. HDAC6 belongs to class II and shares similar …
Examining the stability of binding modes of the co-crystallized inhibitors of human HDAC8 by molecular dynamics simulation
Histone deacetylase (HDAC) 8 has been implicated as a potential therapeutic target in a
variety of cancers, neurodegenerative disorders, metabolic dysregulation and autoimmune …
variety of cancers, neurodegenerative disorders, metabolic dysregulation and autoimmune …
Epigenetic regulation exerted by Caliphruria subedentata and galantamine: an in vitro and in silico approach for mimic Alzheimer's disease
WO Castillo Ordoñez… - Journal of …, 2024 - Taylor & Francis
At the interface between genes and environment, epigenetic mechanisms, including DNA
methylation and histone modification, regulate neurogenic processes such as differentiation …
methylation and histone modification, regulate neurogenic processes such as differentiation …
Structure-based virtual screening for novel potential selective inhibitors of class IIa histone deacetylases for cancer treatment
AD Elmezayen, Y Kemal - Computational Biology and Chemistry, 2021 - Elsevier
The fundamental cause of human cancer is strongly influenced by down-or up-regulations of
epigenetic factors. Upregulated histone deacetylases (HDAC) have been shown to be …
epigenetic factors. Upregulated histone deacetylases (HDAC) have been shown to be …
[HTML][HTML] Exposing the molecular screening method of Indonesian natural products derivate as drug candidates for cervical cancer
USF Tambunan, AA Parikesit… - Iranian journal of …, 2017 - ncbi.nlm.nih.gov
The menace of cervical cancer has reached an alarming rate. There are more than 450.000
cases of cervical cancer yearly, with mortality rate of about 50%. This deadly cancer is …
cases of cervical cancer yearly, with mortality rate of about 50%. This deadly cancer is …
Utilization of Boron Compounds for the Modification of Suberoyl Anilide Hydroxamic Acid as Inhibitor of Histone Deacetylase Class II Homo sapiens
R Bakri, AA Parikesit, CP Satriyanto… - Advances in …, 2014 - Wiley Online Library
Histone deacetylase (HDAC) has a critical function in regulating gene expression. The
inhibition of HDAC has developed as an interesting anticancer research area that targets …
inhibition of HDAC has developed as an interesting anticancer research area that targets …
[HTML][HTML] Synergistic combination of histone deacetylase inhibitor suberoylanilide hydroxamic acid and oncolytic adenovirus ZD55-TRAIL as a therapy against cervical …
X Han, S Wang, W Zhou, Y Li… - Molecular medicine …, 2015 - spandidos-publications.com
Oncolytic adenoviruses (OA) have been investigated as virotherapeutic agents for the
treatment of cervical cancer and thus far results are promising. However, the cytotoxicity of …
treatment of cervical cancer and thus far results are promising. However, the cytotoxicity of …
Docking approaches used in epigenetic drug investigations
Y Sixto-López, J Correa-Basurto - … docking for computer-aided drug design, 2021 - Elsevier
Epigenetics is a term referred to heritable modification which does not involve mutations or
translocations on DNA sequence; but at molecular level, structural modifications on nucleic …
translocations on DNA sequence; but at molecular level, structural modifications on nucleic …