An overview of antitumour activity of polysaccharides

H Jin, M Li, F Tian, F Yu, W Zhao - Molecules, 2022 - mdpi.com
Cancer incidence and mortality are rapidly increasing worldwide; therefore, effective
therapies are required in the current scenario of increasing cancer cases. Polysaccharides …

Chondroitin Sulphate: An emerging therapeutic multidimensional proteoglycan in colon cancer

AT Mneimneh, MM Mehanna - International Journal of Biological …, 2024 - Elsevier
Chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG) that has captured massive
attention in the field of drug delivery. As the colon is considered the preferred site for local …

Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis

X Zheng, J Song, C Yu, Z Zhou, X Liu, J Yu… - … and Targeted Therapy, 2022 - nature.com
The adenoma-carcinoma sequence is a well-accepted roadmap for the development of
sporadic colorectal cancer. However, cellular heterogeneity in aberrant epithelial cells limits …

Antitumor mechanisms of an exopolysaccharide from Lactobacillus fermentum on HT-29 cells and HT-29 tumor-bearing mice

F Li, X Jiao, J Zhao, X Liao, Y Wei, Q Li - International Journal of Biological …, 2022 - Elsevier
We have obtained an exopolysaccharide (YL-11 EPS) produced by Lactobacillus fermentum
YL-11 isolated from fermented milk and confirmed that it can effectively inhibit colon cancer …

A review of chondroitin sulfate's preparation, properties, functions, and applications

Q Shen, Y Guo, K Wang, C Zhang, Y Ma - Molecules, 2023 - mdpi.com
Chondroitin sulfate (CS) is a natural macromolecule polysaccharide that is extensively
distributed in a wide variety of organisms. CS is of great interest to researchers due to its …

Flavonoid-rich extracts from okra flowers exert antitumor activity in colorectal cancer through induction of mitochondrial dysfunction-associated apoptosis, senescence …

Y Deng, S Li, M Wang, X Chen, L Tian, L Wang… - Food & function, 2020 - pubs.rsc.org
Okra flowers contain a higher content of total flavonoids than most other flowers; however
little research has been conducted on their potential benefits, including antitumor activity. In …

Structural analysis and anti-cancer activity of low-molecular-weight chondroitin sulfate from hybrid sturgeon cartilage

R Wu, P Li, Y Wang, N Su, M Xiao, X Li, N Shang - Carbohydrate polymers, 2022 - Elsevier
Low-molecular-weight chondroitin sulfate (CS) has attracted widespread attention due to its
better bioavailability and bioactivity than native CS. In this study, a low-molecular-weight CS …

Sulfoconjugation of protein peptides and glycoproteins in physiology and diseases

P Xu, X Cai, X Guan, W Xie - Pharmacology & Therapeutics, 2023 - Elsevier
Protein sulfoconjugation, or sulfation, represents a critical post-translational modification
(PTM) process that involves the attachment of sulfate groups to various positions of …

Quantification of orally administered chondroitin sulfate oligosaccharides in human plasma and urine

H Mizuta, S Kawahara, N Tsutsumi, N Miyamoto - Glycobiology, 2023 - academic.oup.com
Chondroitin sulfate has been widely administered orally to improve knee osteoarthritis.
Chondroitin sulfate also has various biological properties, such as anti-inflammatory …

The therapeutic potential of chondroitin sulfate in Aspergillus fumigatus keratitis

J Luan, X Peng, J Lin, Y Zhang, X Tian, L Zhan… - Molecular …, 2022 - Elsevier
Purpose To explore the therapeutic effect of chondroitin sulfate (CS) on Aspergillus
fumigatus (A. fumigatus) keratitis. Methods The nontoxic concentration of CS was …