[HTML][HTML] Leveraging knowledge of HDLs major protein ApoA1: Structure, function, mutations, and potential therapeutics

AS Bhale, K Venkataraman - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Abstract Apolipoprotein A1 (ApoA1) is a member of the Apolipoprotein family of proteins. It's
a vital protein that helps in the production of high-density lipoprotein (HDL) particles, which …

Anti-inflammatory mechanism of Apolipoprotein AI

X Tao, R Tao, K Wang, L Wu - Frontiers in Immunology, 2024 - frontiersin.org
Apolipoprotein AI (ApoA-I) is a member of blood apolipoproteins, it is the main component of
High density lipoprotein (HDL). ApoA-I undergoes a series of complex processes from its …

Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health

NJ Merrill, WS Davidson, Y He, I Díaz Ludovico… - Science …, 2023 - science.org
Lipoproteins in cerebrospinal fluid (CSF) of the central nervous system (CNS) resemble
plasma high-density lipoproteins (HDLs), which are a compositionally and structurally …

Apolipoprotein E-containing HDL decreases caspase-dependent apoptosis of memory regulatory T lymphocytes

L Atehortua, J Morris, SE Street, N Bedel… - Journal of Lipid …, 2023 - ASBMB
Plasma levels of HDL cholesterol are inversely associated with CVD progression. It is
becoming increasingly clear that HDL plays important roles in immunity that go beyond its …

Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteins

MR Strickland, MJ Rau, B Summers, K Basore, J Wulf… - Neuron, 2024 - cell.com
Summary The Apolipoprotein E gene (APOE) is of great interest due to its role as a risk
factor for late-onset Alzheimer's disease. ApoE is secreted by astrocytes in the central …

Effects of semaglutide on cardiac protein expression and cardiac function of obese mice

X Pan, L Yue, J Ban, L Ren, S Chen - Journal of Inflammation …, 2022 - Taylor & Francis
Purpose Using proteomics to study the effect of semaglutide on cardiac protein expression
in obese mice. Assessment of the effect of semaglutide on cardiac function in obese mice …

Extracellular vesicle and lipoprotein diagnostics (ExoLP-Dx) with membrane sensor: A robust microfluidic platform to overcome heterogeneity

S Kumar, S Senapati, HC Chang - Biomicrofluidics, 2024 - pubs.aip.org
The physiological origins and functions of extracellular vesicles (EVs) and lipoproteins (LPs)
propel advancements in precision medicine by offering non-invasive diagnostic and …

[HTML][HTML] Efficient Search Algorithms for Identifying Synergistic Associations in High-Dimensional Datasets

C Hourican, J Li, PP Mishra, T Lehtimäki, BH Mishra… - Entropy, 2024 - pmc.ncbi.nlm.nih.gov
In recent years, there has been a notably increased interest in the study of multivariate
interactions and emergent higher-order dependencies. This is particularly evident in the …

The skimmed milk proteome of dairy cows is affected by the stage of lactation and by supplementation with polyunsaturated fatty acids

A Veshkini, HM Hammon, L Vogel, D Viala… - Scientific Reports, 2024 - nature.com
The impact of nutritional modification to increase functional polyunsaturated fatty acids
(PUFA), such as n-3 and n-6 fatty acids (FA) or conjugated linoleic acid (CLA), on milk …

Integrated quantitative targeted lipidomics and proteomics reveal unique fingerprints of multiple metabolic conditions

AA Ivanova, JC Rees, BA Parks, M Andrews… - Biomolecules, 2022 - mdpi.com
Aberrations in lipid and lipoprotein metabolic pathways can lead to numerous diseases,
including cardiovascular disease, diabetes, neurological disorders, and cancer. The …