The regionalization of pediatric services has resulted in differential access to care,
sometimes creating barriers to those living in underserved, rural communities. These …

Sepsis is the leading cause of death in children worldwide. Although the diagnosis and
management of sepsis in infants and children is largely influenced by studies done in adults …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Rationale: Limited data exist about the international burden of severe sepsis in critically ill
children. Objectives: To characterize the global prevalence, therapies, and outcomes of …

Importance The death of a pediatric patient with sepsis motivated New York to mandate
statewide sepsis treatment in 2013. The mandate included a 1-hour bundle of blood …

Objective: To provide an update to the “Surviving Sepsis Campaign Guidelines for
Management of Severe Sepsis and Septic Shock,” last published in 2008. Design: A …

Background Severe infections kill more than 4· 5 million children every year. Population-
based data for severe infections in children requiring admission to intensive care units …

Objectives: To compare the prevalence, resource utilization, and mortality for pediatric
severe sepsis identified using two established identification strategies. Design …

Background: The Institute of Medicine calls for the use of clinical guidelines and practice
parameters to promote “best practices” and to improve patient outcomes. Objective: 2007 …

Background Rapid antibiotic administration is known to improve sepsis outcomes, however
early diagnosis remains challenging due to complex presentation. Our objective was to …