Fish: a suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities

V Laizé, PJ Gavaia, ML Cancela - Drug Discovery Today: Disease Models, 2014 - Elsevier
This review discusses the suitability and advantages of teleost fish for studying underlying
mechanisms of normal and pathological development and mineralization of vertebrate …

Skeletal Morphogenesis and Anomalies in Gilthead Seabream: A Comprehensive Review

K Mhalhel, M Levanti, F Abbate, R Laurà… - International Journal of …, 2023 - mdpi.com
The gilthead seabream, one of the most important species in Mediterranean aquaculture,
with an increasing status of exploitation in terms of production volume and aquafarming …

Screening of mineralogenic and osteogenic compounds in zebrafish—Tools to improve assay throughput and data accuracy

JT Rosa, M Tarasco, PJ Gavaia, ML Cancela, V Laizé - Pharmaceuticals, 2022 - mdpi.com
Bone disorders affect millions of people worldwide and treatments currently available often
produce undesirable secondary effects or have limited efficacy. It is therefore of the utmost …

αKlotho regulates age-associated vascular calcification and lifespan in zebrafish

AP Singh, MX Sosa, J Fang, SK Shanmukhappa… - Cell reports, 2019 - cell.com
The hormone αKlotho regulates lifespan in mice, as knockouts die early of what appears to
be accelerated aging due to hyperphosphatemia and soft tissue calcification. In contrast, the …

Reversal of Doxorubicin-Induced Bone Loss and Mineralization by Supplementation of Resveratrol and MitoTEMPO in the Early Development of Sparus aurata

S Poudel, M Izquierdo, ML Cancela, PJ Gavaia - Nutrients, 2022 - mdpi.com
Doxorubicin is a widely used chemotherapeutic drug known to induce bone loss. The
mechanism behind doxorubicin-mediated bone loss is unclear, but oxidative stress has …

Effect of early peptide diets on zebrafish skeletal development

A Printzi, G Koumoundouros, V Fournier, L Madec… - Biomolecules, 2023 - mdpi.com
Incorporation of dietary peptides has been correlated with decreased presence of skeletal
abnormalities in marine larvae. In an attempt to clarify the effect of smaller protein fractions …

Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives

CL Marques, I Fernández, MN Viegas, CJ Cox… - Cellular and molecular …, 2016 - Springer
Abstract BMP2, BMP4 and BMP16 form a subfamily of bone morphogenetic proteins acting
as pleiotropic growth factors during development and as bone inducers during …

VKORC1 and VKORC1L1: why do vertebrates have two vitamin K 2, 3-epoxide reductases?

J Oldenburg, M Watzka, CG Bevans - Nutrients, 2015 - mdpi.com
Among all cellular life on earth, with the exception of yeasts, fungi, and some prokaryotes,
VKOR family homologs are ubiquitously encoded in nuclear genomes, suggesting ancient …

Development and characterization of a skin cell line (SGA) from the mosquitofish Gambusia affinis and its susceptibility to fish Betanodavirus

P Vijayakumar, M Ravi, R Sudhakaran, T Mekata… - Aquaculture, 2020 - Elsevier
A new continuous cell line designated as SGA has been developed from the skin tissue of
the freshwater mosquitofish Gambusia affinis. The cell line grew well in Leibovitz's L-15 …

Adipogenic gene expression in gilthead sea bream mesenchymal stem cells from different origin

C Salmerón, N Riera-Heredia, J Gutiérrez… - Frontiers in …, 2016 - frontiersin.org
During the last decades, adipogenesis has become an emerging field of study in
aquaculture due to the relevance of the adipose tissue in many physiological processes and …