The stiffness of living tissues and its implications for tissue engineering

CF Guimarães, L Gasperini, AP Marques… - Nature Reviews …, 2020 - nature.com
The past 20 years have witnessed ever-growing evidence that the mechanical properties of
biological tissues, from nanoscale to macroscale dimensions, are fundamental for cellular …

Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses

LA Costa, N Eiro, M Fraile, LO Gonzalez, J Saá… - Cellular and Molecular …, 2021 - Springer
Mesenchymal stem cells (MSC) are present in all organs and tissues. Several studies have
shown the therapeutic potential effect of MSC or their derived products. However, the …

Cell membrane-camouflaged nanocarriers with biomimetic deformability of erythrocytes for ultralong circulation and enhanced cancer therapy

Y Miao, Y Yang, L Guo, M Chen, X Zhou, Y Zhao… - ACS …, 2022 - ACS Publications
Despite considerable advancements in cell membrane-camouflaged nanocarriers to
leverage natural cell functions, artificial nanocarriers that can accurately mimic both the …

Investigating cell mechanics with atomic force microscopy

K Haase, AE Pelling - Journal of The Royal Society …, 2015 - royalsocietypublishing.org
Transmission of mechanical force is crucial for normal cell development and functioning.
However, the process of mechanotransduction cannot be studied in isolation from cell …

Standardized nanomechanical atomic force microscopy procedure (SNAP) for measuring soft and biological samples

H Schillers, C Rianna, J Schäpe, T Luque… - Scientific reports, 2017 - nature.com
We present a procedure that allows a reliable determination of the elastic (Young's) modulus
of soft samples, including living cells, by atomic force microscopy (AFM). The standardized …

Impact of aging on the regenerative properties of bone marrow-, muscle-, and adipose-derived mesenchymal stem/stromal cells

OS Beane, VC Fonseca, LL Cooper, G Koren… - PloS one, 2014 - journals.plos.org
Mesenchymal stem/stromal cells (MSCs) are promising cell sources for regenerative
therapies due to their multipotency and ready availability, but their application can be …

[HTML][HTML] On the origin and impact of mesenchymal stem cell heterogeneity: new insights and emerging tools for single cell analysis

CM McLeod, RL Mauck - European cells & materials, 2017 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) display substantial cell-to-cell variation. This heterogeneity
manifests among donors, among tissue sources, and within cell populations. Such pervasive …

Rare cell isolation and analysis in microfluidics

Y Chen, P Li, PH Huang, Y Xie, JD Mai, L Wang… - Lab on a Chip, 2014 - pubs.rsc.org
Rare cells are low-abundance cells in a much larger population of background cells.
Conventional benchtop techniques have limited capabilities to isolate and analyze rare cells …

Specificity of 3D MSC spheroids microenvironment: impact on MSC behavior and properties

A Jauković, D Abadjieva, D Trivanović… - Stem cell reviews and …, 2020 - Springer
Mesenchymal stem cells (MSC) have been considered the promising candidates for the
regenerative and personalized medicine due to their self-renewal potential, multilineage …

Tissue engineering and regenerative medicine: recent innovations and the transition to translation

MB Fisher, RL Mauck - Tissue Engineering Part B: Reviews, 2013 - liebertpub.com
The field of tissue engineering and regenerative medicine (TERM) has exploded in the last
decade. In this Year (or so) in Review, we highlight some of the high impact advances within …