Chronic pain is a severely debilitating condition that reflects a long-term sensitization of
signal transduction in the afferent pain pathway. Among the key players in this pathway are …

Trigeminal nerve injury is one of the causes of chronic orofacial pain. Patients suffering from
this condition have a significantly reduced quality of life. The currently available …

microRNA (miRNA)–mediated gene regulation has been studied as a therapeutic approach,
but its functional regulatory mechanism in neuropathic pain is not well understood. Here, we …

Trigeminal neuralgia (TN) is a rare but debilitating disorder characterized by excruciating
facial pain, with a higher incidence in women. Recent studies demonstrated that TN patients …

Trigeminal neuralgia (TN) is a severe facial pain disease of unknown cause and unclear
genetic background. To examine the existing knowledge about genetics in TN, we …

Noxious stimuli like cold, heat, pH change, tissue damage, and inflammation depolarize a
membrane of peripheral endings of specialized nociceptive neurons which eventually …

Abstract Thrombospondin-4 (TSP-4) belongs to the extracellular matrix glycoprotein family of
thrombospondins (TSPs). The multidomain, pentameric structure of TSP-4 allows its …

Chronic pain affects approximately one-fifth of people worldwide and reduces quality of life
and in some cases, working ability. Ion channels expressed along nociceptive pathways …

Neuropathic pain (NP) is a typical symptom of peripheral nerve disorders, including painful
neuropathy. The biological mechanisms that control ion channels are important for many cell …

Orofacial pain (OFP) is a dental specialty that includes the diagnosis, management and
treatment of disorders of the jaw, mouth, face, head and neck. Evidence-based …