Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus

AA Tahrani, AH Barnett, CJ Bailey - Nature Reviews Endocrinology, 2016 - nature.com
Type 2 diabetes mellitus (T2DM) is a global epidemic that poses a major challenge to health-
care systems. Improving metabolic control to approach normal glycaemia (where practical) …

Impact of GLP-1 receptor agonists on blood pressure, heart rate and hypertension among patients with type 2 diabetes: a systematic review and network meta …

F Sun, S Wu, S Guo, K Yu, Z Yang, L Li, Y Zhang… - Diabetes research and …, 2015 - Elsevier
Aims To evaluate current evidence of glucagon-like peptide-1 receptor agonists (GLP-1RAs)
on blood pressure, heart rate, and hypertension in patients with type 2 diabetes. Methods …

[HTML][HTML] Adverse effects of GLP-1 receptor agonists

TD Filippatos, TV Panagiotopoulou… - The review of diabetic …, 2014 - ncbi.nlm.nih.gov
Abstract Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of injective anti-
diabetic drugs that improve glycemic control and many other atherosclerosis-related …

Effect of semaglutide on liver enzymes and markers of inflammation in subjects with type 2 diabetes and/or obesity

P Newsome, S Francque, S Harrison… - Alimentary …, 2019 - Wiley Online Library
Background Obesity and type 2 diabetes are drivers of non‐alcoholic fatty liver disease
(NAFLD). Glucagon‐like peptide‐1 analogues effectively treat obesity and type 2 diabetes …

Weight loss effect of glucagon‐like peptide‐1 mimetics on obese/overweight adults without diabetes: A systematic review and meta‐analysis of randomized controlled …

F Zhang, Y Tong, N Su, Y Li, L Tang… - Journal of …, 2015 - Wiley Online Library
摘要背景: 胰高血糖素样肽‐1 (glucagon‐like peptide 1, GLP‐1) 受体激动剂对维持糖尿病患者
的体重有益. 我们通过分析以往的随机对照试验来了解该类药物在非糖尿病的肥胖/超重人群中 …

GLP-1 receptor agonists and diabetic kidney disease: a call of attention to nephrologists

JL Górriz, MJ Soler, JF Navarro-González… - Journal of clinical …, 2020 - mdpi.com
Type 2 diabetes mellitus (T2DM) represents the main cause of chronic kidney disease
(CKD) and end-stage renal disease (ESKD), and diabetic kidney disease (DKD) is a major …

Systolic blood pressure reduction with tirzepatide in patients with type 2 diabetes: insights from SURPASS clinical program

I Lingvay, O Mosenzon, K Brown, X Cui… - Cardiovascular …, 2023 - Springer
Background Tirzepatide, a once-weekly glucose-dependent insulinotropic
polypeptide/glucagon-like peptide-1 receptor agonist, is approved in the United States …

NAFLD in the Elderly

SA Alqahtani, JM Schattenberg - Clinical interventions in aging, 2021 - Taylor & Francis
Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent disease globally.
Current estimates are that 24% of the adult population, thus, one billion individuals …

Metabolic-Dysfunction-Associated Steatotic Liver Disease—Its Pathophysiology, Association with Atherosclerosis and Cardiovascular Disease, and Treatments

H Yanai, H Adachi, M Hakoshima, S Iida… - International journal of …, 2023 - mdpi.com
Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a chronic liver disease
that affects more than a quarter of the global population and whose prevalence is increasing …

A review of GLP‐1 receptor agonists in type 2 diabetes: a focus on the mechanism of action of once‐weekly agents

S Cornell - Journal of clinical pharmacy and therapeutics, 2020 - Wiley Online Library
What is known and objective Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are
one of the preferred approved treatment options for people with type 2 diabetes (T2D) and …