Synthesis of new bis(pyrazolo[1,5-a]pyrimidines) linked to different spacers with potential MurB inhibitory activity utilizing 1H-pyrazole-3,5-diamines
Recently, there has been an increased interest in developing new antibacterial agents that
target the MurB inhibition, which is necessary for bacterial survival. We developed a two …
target the MurB inhibition, which is necessary for bacterial survival. We developed a two …
Structural and Functional Insights into UDP-N-acetylglucosamine-enolpyruvate Reductase (MurB) from Brucella ovis
M Minjárez-Sáenz, M Rivero, V Correa-Pérez… - Archives of Biochemistry …, 2025 - Elsevier
The peptidoglycan biosynthetic pathway involves a series of enzymatic reactions in which
UDP-N-acetylglucosamine-enolpyruvate reductase (MurB) plays a crucial role in catalyzing …
UDP-N-acetylglucosamine-enolpyruvate reductase (MurB) plays a crucial role in catalyzing …