[HTML][HTML] Selection of genetic instruments in Mendelian randomisation studies of sleep traits

V Paz, HS Dashti, S Burgess, V Garfield - Sleep medicine, 2023 - Elsevier
This review explores the criteria used for the selection of genetic instruments of sleep traits
in the context of Mendelian randomisation studies. This work was motivated by the fact that …

Targeting sulfation-dependent mechanoreciprocity between matrix and osteoblasts to mitigate bone loss

C Zheng, H Liu, P Zhao, W Lu, S Song, T He… - Science Translational …, 2023 - science.org
Sulfation is a widespread modification of biomolecules that has been incompletely explored
to date. Through cross-phenotype meta-analysis of bone mineral density in up to 426,824 …

Association between sarcopenia and fracture risk in a population from the UK biobank database

C Jauffret, R Périchon, A Lamer, B Cortet… - Journal of Bone and …, 2023 - academic.oup.com
Studies on the fracture risk in presarcopenic and sarcopenic patients report contradictory
results. The objective was to assess whether presarcopenia and sarcopenia are associated …

Both indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass

JW Xia, L Zhang, J Li, CD Yuan, XW Zhu, Y Qian… - BMC medicine, 2022 - Springer
Background Birth weight is considered not only to undermine future growth, but also to
induce lifelong diseases; the aim of this study is to explore the relationship between birth …

Sleep deprivation causes gut dysbiosis impacting on systemic metabolomics leading to premature ovarian insufficiency in adolescent mice

J Yan, X Zhang, K Zhu, M Yu, Q Liu, M De Felici… - …, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Currently, there are occasional reports of health problems caused by sleep
deprivation (SD). However, to date, there remains a lack of in-depth research regarding the …

Risk factors of falls in elderly patients with visual impairment

S Ouyang, C Zheng, Z Lin, X Zhang, H Li… - Frontiers in public …, 2022 - frontiersin.org
Objective To examine the risk factors for falls in elderly patients with visual impairment (VI)
and assess the predictive performance of these factors. Methods Between January 2019 …

Deciphering the complex relationship between type 2 diabetes and fracture risk with both genetic and observational evidence

P Zhao, Z Sheng, L Xu, P Li, W Xiao, C Yuan, Z Xu… - Elife, 2024 - elifesciences.org
The 'diabetic bone paradox'suggested that type 2 diabetes (T2D) patients would have higher
areal bone mineral density (BMD) but higher fracture risk than individuals without T2D. In …

Frequently reported adverse events of rebamipide compared to other drugs for peptic ulcer and gastroesophageal reflux disease

E Jang, M Park, JE Jeong, JY Lee, MG Kim - Scientific Reports, 2022 - nature.com
This study aimed to detect safety signals of rebamipide and search for adverse events (AEs)
of rebamipide that are more common than those of other drugs for peptic ulcer disease …

[HTML][HTML] Deciphering the relationship between type 2 diabetes and fracture risk: the genetic and observational evidences

P Zhao, Z Sheng, L Xu, P Li, W Xiao, C Yuan, Z Xu… - Elife, 2023 - elifesciences.org
The “diabetic bone paradox” suggested that type 2 diabetes (T2D) patients would have
higher bone mineral density (BMD) but higher fracture risk than individuals without T2D. In …

Ambient Exposure and Bone Homeostasis: Analysis of UK Biobank Data and Experimental Studies in Mice and in Vitro

Q Ge, S Yang, Y Qian, J Chen, W Yuan… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: Previous evidence has identified exposure to fine ambient particulate matter
(PM 2.5) as a leading risk factor for adverse health outcomes. However, to date, only a few …