Imidazopyridine-based kinase inhibitors as potential anticancer agents: A review
Considering the fundamental role of protein kinases in the mechanism of protein
phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has …
phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has …
Microvascular experimentation in the chick chorioallantoic membrane as a model for screening angiogenic agents including from gene-modified cells
DC Kennedy, B Coen, AM Wheatley… - International journal of …, 2021 - mdpi.com
The chick chorioallantoic membrane (CAM) assay model of angiogenesis has been
highlighted as a relatively quick, low cost and effective model for the study of pro-angiogenic …
highlighted as a relatively quick, low cost and effective model for the study of pro-angiogenic …
Antiangiogenesis Efficacy of Ethanol Extract from Amomum tsaoko in Ovarian Cancer through Inducing ER Stress to Suppress p‐STAT3/NF‐kB/IL‐6 and VEGF Loop
C Chen, F You, FH Wu, YS Luo… - Evidence‐Based …, 2020 - Wiley Online Library
Natural plants are considered as a huge treasure for anticancer. Amomum tsaoko, a plant of
Zingiberaceae, is used widely as a food and traditional medicine in East Asia. In previous …
Zingiberaceae, is used widely as a food and traditional medicine in East Asia. In previous …
The role of heparan sulfate and neuropilin 2 in VEGFA signaling in human endothelial tip cells and non-tip cells during angiogenesis in vitro
MG Dallinga, YI Habani, AWM Schimmel… - Cells, 2021 - mdpi.com
During angiogenesis, vascular endothelial growth factor A (VEGFA) regulates endothelial
cell (EC) survival, tip cell formation, and stalk cell proliferation via VEGF receptor 2 …
cell (EC) survival, tip cell formation, and stalk cell proliferation via VEGF receptor 2 …
Identification of low-dose multidrug combinations for sunitinib-naive and pre-treated renal cell carcinoma
M Rausch, A Weiss, J Achkhanian, A Rotari… - British journal of …, 2020 - nature.com
Background Combinations of drugs can improve the efficacy of cancer treatment, enable the
reduction of side effects and the occurrence of acquired drug resistance. Methods We …
reduction of side effects and the occurrence of acquired drug resistance. Methods We …
Colorectal cancer growth retardation through induction of apoptosis, using an optimized synergistic cocktail of axitinib, erlotinib, and dasatinib
RH Berndsen, N Swier, JR van Beijnum… - Cancers, 2019 - mdpi.com
Patients with advanced colorectal cancer (CRC) still depend on chemotherapy regimens
that are associated with significant limitations, including resistance and toxicity. The …
that are associated with significant limitations, including resistance and toxicity. The …
A preliminary study on the characteristics of micrornas in ovarian stroma and follicles of chuanzhong black goat during estrus
T Lu, X Zou, G Liu, M Deng, B Sun, Y Guo, D Liu, Y Li - Genes, 2020 - mdpi.com
microRNAs (miRNAs) play a significant role in ovarian follicular maturity, but miRNA
expression patterns in ovarian stroma (OS), large follicles (LF), and small follicles (SF) have …
expression patterns in ovarian stroma (OS), large follicles (LF), and small follicles (SF) have …
Integrating phenotypic search and phosphoproteomic profiling of active kinases for optimization of drug mixtures for RCC treatment
JR van Beijnum, A Weiss, RH Berndsen, TJ Wong… - Cancers, 2020 - mdpi.com
Simple Summary Renal cell carcinoma (RCC) cancer is among the ten most common
malignancies, and frequently presents as metastatic disease (mRCC). For these patients …
malignancies, and frequently presents as metastatic disease (mRCC). For these patients …
Drugs in the GIST field (therapeutic targets and clinical trial staging)
C Huang, X Ma, M Wang, H Cao - Current Drug Delivery, 2024 - benthamdirect.com
Background: Molecular targeted therapies are the most important type of medical treatment
for GIST, but the development of GIST drugs and their targets have not been summarized …
for GIST, but the development of GIST drugs and their targets have not been summarized …
Stromal PDGFR-beta expression is a prognostic factor in high-grade serous ovarian cancer patients but is it also predictive for response to antiangiogenic treatment?
A Volk, C von Bülow, A Stern, R Simon… - Journal of Cancer …, 2025 - Springer
Objective In advanced ovarian cancer, the majority of patients receive anti-angiogenic
treatment with bevacizumab. However, its use is often associated with severe side effects …
treatment with bevacizumab. However, its use is often associated with severe side effects …