Recent studies show that alloantibodies mediate a substantial proportion of graft-rejection
episodes, contributing to both early and late graft loss. Rejection that is caused by antibody …

Under the direction of the International Society for Heart and Lung Transplantation, a
multidisciplinary review of the cardiac biopsy grading system was undertaken in 2004, with …

Background. Mesenchymal stem cells (MSC) are pluripotent progenitors for a variety of cell
types, including fibroblasts and muscle cells. Their involvement in the tissue repair of …

The etiology of immunologically mediated chronic renal allograft failure is unclear. One
cause is thought to be alloantibodies. Previously in Cynomolgus monkeys, we observed a …

The development of reliable in vitro assays that could allow the quantitation and
characterization of anti‐donor alloimmune responses has always been a goal in clinical …

The role of alloantibodies against HLA and non-HLA targets is becoming increasingly
recognized as critical in the pathogenesis of acute and chronic renal allograft outcomes …

The clinical importance of HLA-specific antibodies for organ allograft outcome is well
established. In the past few years, there has been an increasing interest in non-HLA …

Chronic transplant vasculopathy (CTV) is a progressive form of vascular obliteration
affecting the arteries, arterioles and capillaries of solid organ transplants. It is characterized …

Endothelial cells (ECs) apoptosis is an initial event in transplant arteriosclerosis (TA),
resulting in allograft function loss. To elucidate the precise mechanisms of ECs apoptosis …

The development of antibodies (Abs) to major histocompatibility (MHC) class I–related chain
A (MICA) and human leukocyte antigen (HLA) and their role in the immunopathogenesis of …