Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …

The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved
cytokines whose signalling modulates cell fate decision-making across varying cellular …

The transforming growth factor-β (TGF-β) family of ligands elicit their biological effects by
initiating new programs of gene expression. The best understood signal transducers for …

Transforming growth factor β (TGFβ) pathways are implicated in metazoan development,
adult homeostasis and disease. TGFβ ligands signal via receptor serine/threonine kinases …

TGF-β superfamily signaling pathways emerged with the evolution of multicellular animals,
suggesting that these pathways contribute to the increased diversity and complexity required …

Members of the transforming growth factor-β (TGF-β) family have important roles during
embryogenesis, as well as in the control of tissue homeostasis in the adult. They exert their …

Transforming growth factor-β (TGFβ) is the prototype for a large family of pleiotropic factors
that signal via heterotetrameric complexes of type I and type II serine/threonine kinase …

The assembly of the Smad complex is critical for TGFβ signaling, yet the mechanisms that
inactivate or empower nuclear Smad complexes are less understood. By means of siRNA …

Epithelial to mesenchymal transition (EMT) plays an important role in embryonic
development, tissue regeneration, and cancer metastasis. Whereas several feedback loops …

Triple-negative breast cancers (TNBC), characterized by absence of estrogen receptor (ER),
progesterone receptor (PR) and lack of overexpression of human epidermal growth factor …