Inflammation is the key host-defense response to infection and injury, yet also a major
contributor to a diverse range of diseases, both peripheral and central in origin. Brain injury …

The interleukin-1 receptor type 1 (IL-1R1) holds pivotal roles in the immune system, as it is
positioned at the “epicenter” of the inflammatory signaling networks. Increased levels of the …

The IL-36 family belongs to a larger IL-1 superfamily and consists of three agonists (IL-
36α/β/γ), one antagonist (IL-36Ra), one cognate receptor (IL-36R) and one accessory …

Interleukin-1β (IL-1β) is one of the most potent pro-inflammatory cytokines implicated in a
wide range of autoinflammatory, autoimmune, infectious, and degenerative diseases …

Cell-based therapies are emerging as new promising treatments in stroke. However, their
functional mechanism and therapeutic potential during early infarct maturation has so far …

IL-36 cytokines are pro-inflammatory members of the IL-1 family that are upregulated in
inflammatory disorders. Specifically, IL-36γ is highly expressed in active psoriatic lesions …

The interleukin-1 (IL-1) family is involved in the correct functioning and regulation of the
innate immune system, linking innate and adaptative immune responses. This complex …

The motor symptoms of Parkinson's disease are due to the progressive degeneration of
dopaminergic neurons in the substantia nigra. Multiple neuroinflammatory processes are …

Abstract Development of novel drugs for treatment of chronic inflammatory diseases is to a
large extent dependent on the availability of good experimental in vivo models in order to …

Current medical approaches to control the Covid-19 pandemic are either to directly target
the SARS-CoV-2 via innovate a defined drug and a safe vaccine or indirectly target the …