Sickle cell disease results in numerous complications that can lead to significant morbidity
and mortality. Amongst them, acute chest syndrome is the leading cause of mortality. As a …

Beta-like globin gene expression is developmentally regulated during life by transcription
factors, chromatin looping and epigenome modifications of the β-globin locus. Epigenome …

Sickle cell disease (SCD) is caused by a single point mutation in the β-chain of the
hemoglobin gene that results in the replacement of glutamic acid with valine in the …

The aim of this study was to elaborate a booklet for health follow-up and guidance on sickle
cell disease for relatives of children with this disease and validate it. It is a methodological …

Transfusion therapy is a common practice in the treatment of anaemia and can cause
erythrocyte alloimmunisation. To systematise data related to erythrocyte alloimmunisation in …

The hyperactivation and overexpression of critical oncogenes is a common occurrence in
multiple types of malignant tumors. Recently, the abnormal activation mechanism of an …

In this mini-review, we examine very recent (≤ 3 years) endeavors in electrochemical
genosensor design and applications. Electrochemical genosensors are engineered working …

Objetivou-se elaborar uma caderneta de acompanhamento e orientação em saúde sobre a
doença falciforme para familiares de crianças com essa enfermidade, e realizar a sua …

Abstract Sickle Cell Disease (SCD) is a debilitating hematological disorder that affects 1 out
of every 365 African-American births with an even greater prevalence worldwide. The …

La enfermedad de células falciformes es una hemoglobinopatía autosómica recesiva
producida por la mutación del gen de la cadena β-globina, que genera la sustitución de …