METTL3-mediated m6A modification of LINC00839 maintains glioma stem cells and radiation resistance by activating Wnt/β-catenin signaling

J Yin, F Ding, Z Cheng, X Ge, Y Li, A Zeng… - Cell death & …, 2023 - nature.com
Long noncoding RNAs (lncRNAs) are involved in glioma initiation and progression. Glioma
stem cells (GSCs) are essential for tumor initiation, maintenance, and therapeutic resistance …

Mechanisms of breast cancer progression induced by environment-polluting aryl hydrocarbon receptor agonists

NV Miret, CA Pontillo, S Buján, FA Chiappini… - Biochemical …, 2023 - Elsevier
Breast cancer is the most common invasive malignancy among women worldwide and
constitutes a complex and heterogeneous disease. Interest has recently grown in the role of …

A spotlight on the interplay between Wnt/β-catenin signaling and circular RNAs in hepatocellular carcinoma progression

A Mafi, H Rismanchi, M Malek Mohammadi… - Frontiers in …, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the deadliest cancers due to multifocal
development and distant metastasis resulting from late diagnosis. Consequently, new …

[HTML][HTML] Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities

Y Katsumata, LM Shade, TJ Hohman… - Neurobiology of …, 2022 - Elsevier
The classic pathologic hallmarks of Alzheimer's disease (AD) are amyloid plaques and
neurofibrillary tangles (AD neuropathologic changes, or ADNC). However, brains from …

Cancer stem cells in pancreatic ductal adenocarcinoma

R Bubin, R Uljanovs, I Strumfa - International Journal of Molecular …, 2023 - mdpi.com
The first discovery of cancer stem cells (CSCs) in leukaemia triggered active research on
stemness in neoplastic tissues. CSCs represent a subpopulation of malignant cells, defined …

The potent role of Src kinase-regulating glucose metabolism in cancer

W Shao, L Liu, F Zheng, Y Ma, J Zhang - Biochemical pharmacology, 2022 - Elsevier
Src kinase is a membrane-related nonreceptor tyrosine kinase that plays an essential role in
cell growth, division, migration, and survival signaling pathways. In addition, it regulates …

Preventive effect of pharmaceutical phytochemicals targeting the Src family of protein tyrosine kinases and aryl hydrocarbon receptor on environmental stress-induced …

SJ Paik, DJ Kim, SK Jung - International Journal of Molecular Sciences, 2023 - mdpi.com
The skin protects our body; however, it is directly exposed to the environment and is
stimulated by various external factors. Among the various environmental factors that can …

Effects of cadherin mediated contact normalization on oncogenic Src kinase mediated gene expression and protein phosphorylation

RE Nicoletto, CJ Holdcraft, AC Yin, EP Retzbach… - Scientific Reports, 2024 - nature.com
Nontransformed cells form heterotypic cadherin junctions with adjacent transformed cells to
inhibit tumor cell growth and motility. Transformed cells must override this form of growth …

CCN3, POSTN, and PTHLH as potential key regulators of genomic integrity and cellular survival in iPSCs

NT Swaidan, NH Soliman, AT Aboughalia… - Frontiers in Molecular …, 2024 - frontiersin.org
Reprogramming human somatic cells into a pluripotent state, achieved through the
activation of well-defined transcriptional factors known as OSKM factors, offers significant …

Fusobacterium nucleatum modulates the Wnt/β-catenin pathway in colorectal cancer development

T Mondal, D Chattopadhyay, PS Mondal, S Das… - International Journal of …, 2025 - Elsevier
The Wnt/β-catenin signalling pathway normally maintains cellular and tissue homeostasis by
regulating cellular differentiation and survival in a controlled manner. An aberrantly …