Peripheral nerve injuries represent a significant problem in public health, constituting 2–5%
of all trauma cases. For severe nerve injuries, even advanced forms of clinical intervention …

Peripheral polyneuropathy is a common and dose-limiting side effect of many important
chemotherapeutic agents. Most such neuropathies are characterized by early axonal …

Obesity is one of the major health issues in the United States. Consumption of diets rich in
energy, notably from fats and sugars (high-fat/high-sugar diet: HF/HSD) is linked to the …

Axon degeneration is an evolutionarily conserved pathway that eliminates damaged or
unneeded axons. Manipulation of this poorly understood pathway may allow treatment of a …

Traumatic peripheral nerve injuries are common and often result in partial or permanent
paralysis, numbness of the affected limb, and debilitating neuropathic pain. Experimental …

Background In response to injury, neurons activate a program of organized axon self-
destruction initiated by the NAD+ hydrolase, SARM1. In healthy neurons SARM1 is …

Autografting is the gold standard in the repair of peripheral nerve injuries that are not
amenable to end‐to‐end coaptation. However, because autografts result in donor‐site …

Mitochondrial dysfunction is a common cause of peripheral neuropathy. Much effort has
been devoted to examining the role played by neuronal/axonal mitochondria, but how …

Introduction: Processed nerve allografts offer a promising alternative to nerve autografts in
the surgical management of peripheral nerve injuries where short deficits exist. Methods …

Axonal degeneration (AxD) following nerve injury, chemotherapy, and in several
neurological disorders is an active process driven by SARM1, an injury-activated NADase …