[HTML][HTML] Rotaviruses

U Desselberger - Virus research, 2014 - Elsevier
Recent advances of rotavirus (RV) basic and applied research are reviewed. They consist of
determination of the RV particle structure and functions of structural proteins, classification …

Rotavirus particle disassembly and assembly in vivo and in vitro

D Asensio-Cob, JM Rodríguez, D Luque - Viruses, 2023 - mdpi.com
Rotaviruses (RVs) are non-enveloped multilayered dsRNA viruses that are major etiologic
agents of diarrheal disease in humans and in the young in a large number of animal …

[HTML][HTML] Milk oligosaccharides inhibit human rotavirus infectivity in MA104 cells

DR Laucirica, V Triantis, R Schoemaker, MK Estes… - The Journal of …, 2017 - Elsevier
Background: Oligosaccharides in milk act as soluble decoy receptors and prevent pathogen
adhesion to the infant gut. Milk oligosaccharides reduce infectivity of a porcine rotavirus …

Advances in the development of antivirals for rotavirus infection

L Jiang, A Tang, L Song, Y Tong, H Fan - Frontiers in Immunology, 2023 - frontiersin.org
Rotavirus (RV) causes 200,000 deaths per year and imposes a serious burden to public
health and livestock farming worldwide. Currently, rehydration (oral and intravenous) …

Rotavirus entry: a deep journey into the cell with several exits

CF Arias, D Silva-Ayala, S López - Journal of virology, 2015 - Am Soc Microbiol
Rotaviruses are the leading etiological agents of acute gastroenteritis in infants and young
children worldwide. These nonenveloped viruses enter cells using different types of …

Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells

S Ding, S Zhu, L Ren, N Feng, Y Song, X Ge, B Li… - Elife, 2018 - elifesciences.org
Rotaviruses (RVs), a leading cause of severe diarrhea in young children and many
mammalian species, have evolved multiple strategies to counteract the host innate …

[HTML][HTML] 25-Hydroxycholesterol and 27-hydroxycholesterol inhibit human rotavirus infection by sequestering viral particles into late endosomes

A Civra, R Francese, P Gamba, G Testa, V Cagno… - Redox biology, 2018 - Elsevier
A novel innate immune strategy, involving specific cholesterol oxidation products as
effectors, has begun to reveal connections between cholesterol metabolism and immune …

Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors

CB Harper, MR Popoff, A McCluskey, PJ Robinson… - Trends in cell …, 2013 - cell.com
Many pathogens hijack existing endocytic trafficking pathways to exert toxic effects in cells.
Dynamin controls various steps of the intoxication process used by numerous pathogenic …

Host serine proteases TMPRSS2 and TMPRSS11D mediate proteolytic activation and trypsin-independent infection in group A rotaviruses

M Sasaki, Y Itakura, M Kishimoto, K Tabata… - Journal of …, 2021 - Am Soc Microbiol
Group A rotaviruses (RVAs) are representative enteric virus species and major causes of
diarrhea in humans and animals. The RVA virion is a triple-layered particle, and the …

Rotavirus cell entry: not so simple after all

CF Arias, S López - Current opinion in virology, 2021 - Elsevier
Rotaviruses are important agents of severe gastroenteritis in young children, and show a
very selective cell and tissue tropism, as well as significant age and host restriction. In the …