Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer

L Colucci-D'Amato, L Speranza, F Volpicelli - International journal of …, 2020 - mdpi.com
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …

Milk fatty acid profiles in different animal species: Focus on the potential effect of selected pufas on metabolism and brain functions

MP Mollica, G Trinchese, F Cimmino, E Penna… - Nutrients, 2021 - mdpi.com
Milk contains several important nutrients that are beneficial for human health. This review
considers the nutritional qualities of essential fatty acids (FAs), especially omega-3 (ω-3) …

High-fat diet induces neuroinflammation and mitochondrial impairment in mice cerebral cortex and synaptic fraction

G Cavaliere, G Trinchese, E Penna… - Frontiers in cellular …, 2019 - frontiersin.org
Brain mitochondrial dysfunction is involved in the development of neurological and
neurodegenerative diseases. Mitochondria specifically located at synapses play a key role …

Interplay between peripheral and central inflammation in obesity-promoted disorders: The impact on synaptic mitochondrial functions

M Crispino, G Trinchese, E Penna, F Cimmino… - International journal of …, 2020 - mdpi.com
The metabolic dysfunctions induced by high fat diet (HFD) consumption are not limited to
organs involved in energy metabolism but cause also a chronic low-grade systemic …

Sleep memory processing: the sequential hypothesis

A Giuditta - Frontiers in systems neuroscience, 2014 - frontiersin.org
According to the sequential hypothesis (SH) memories acquired during wakefulness are
processed during sleep in two serial steps respectively occurring during slow wave sleep …

Presynaptic protein synthesis and brain plasticity: from physiology to neuropathology

C Perrone-Capano, F Volpicelli, E Penna… - Progress in …, 2021 - Elsevier
To form and maintain extremely intricate and functional neural circuitry, mammalian neurons
are typically endowed with highly arborized dendrites and a long axon. The synapses that …

Neurodevelopmental disorders: effect of high-fat diet on synaptic plasticity and mitochondrial functions

E Penna, A Pizzella, F Cimmino, G Trinchese… - Brain Sciences, 2020 - mdpi.com
Neurodevelopmental disorders (NDDs) include diverse neuropathologies characterized by
abnormal brain development leading to impaired cognition, communication and social skills …

Deregulated local protein synthesis in the brain synaptosomes of a mouse model for Alzheimer's disease

C Cefaliello, E Penna, C Barbato, G Di Ruberto… - Molecular …, 2020 - Springer
While protein synthesis in neurons is largely attributed to cell body and dendrites, the
capability of synaptic regions to synthesize new proteins independently of the cell body has …

Butyrate improves neuroinflammation and mitochondrial impairment in cerebral cortex and synaptic fraction in an animal model of diet-induced obesity

G Cavaliere, A Catapano, G Trinchese, F Cimmino… - Antioxidants, 2022 - mdpi.com
Neurodegenerative diseases (NDDs) are characterized by cognitive impairment and
behavioural abnormalities. The incidence of NDDs in recent years has increased globally …

The glutamatergic synapse: a complex machinery for information processing

V Di Maio - Cognitive Neurodynamics, 2021 - Springer
Being the most abundant synaptic type, the glutamatergic synapse is responsible for the
larger part of the brain's information processing. Despite the conceptual simplicity of the …