Prodrugs are molecules with little or no pharmacological activity that are converted to the
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two …

Safety and efficacy constitute the major criteria governing regulatory approval of any new
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …

Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases.
It is characterized by uncontrolled cell proliferation and an absence of cell death that, except …

Modification of biopharmaceutical molecules by covalent conjugation of polyethylene glycol
(PEG) molecules is known to enhance pharmacologic and pharmaceutical properties of …

The field of polymeric nanoparticles is quickly expanding and playing a pivotal role in a wide
spectrum of areas ranging from electronics, photonics, conducting materials, and sensors to …

Advanced drug delivery systems using poly (ethylene glycol)(PEG) is an important
development in anti-cancer therapy. PEGylation has the ability to enhance the retention time …

PEGylation is the covalent addition of PEG to one more molecule. PEGylation can improve
the maintenance time of the therapeutics similar to proteins, liposomes, and nanoparticle …

Use of biodegradable polymers for biomedical applications has increased in recent decades
due to their biocompatibility, biodegradability, flexibility, and minimal side effects …

Polyethylene glycol (PEG) is a biocompatible polymer that is often attached to therapeutic
molecules to improve bioavailability and therapeutic efficacy. Although antibodies with …

The problems associated with hydrophobic anticancer drugs are among the most important
challenges to achieve efficient therapeutics for cancer treatment. In this study, PEGylated …