[HTML][HTML] The future of pharmaceutical manufacturing sciences

J Rantanen, J Khinast - Journal of pharmaceutical sciences, 2015 - Elsevier
The entire pharmaceutical sector is in an urgent need of both innovative technological
solutions and fundamental scientific work, enabling the production of highly engineered …

A comprehensive review on process and engineering aspects of pharmaceutical wet granulation

P Suresh, I Sreedhar, R Vaidhiswaran… - Chemical Engineering …, 2017 - Elsevier
Wet granulation is a very important unit operation that finds applications in many industries
mainly pharmaceutical and chemical industries. Various granulation technologies in batch …

Assessment of recent process analytical technology (PAT) trends: a multiauthor review

LL Simon, H Pataki, G Marosi, F Meemken… - … Process Research & …, 2015 - ACS Publications
This multiauthor review article aims to bring readers up to date with some of the current
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …

An integrated approach for dynamic flowsheet modeling and sensitivity analysis of a continuous tablet manufacturing process

F Boukouvala, V Niotis, R Ramachandran… - Computers & chemical …, 2012 - Elsevier
Manufacturing of powder-based products is a focus of increasing research in the recent
years. The main reason is the lack of predictive process models connecting process …

An engineering study on the enhanced control and operation of continuous manufacturing of pharmaceutical tablets via roller compaction

R Singh, M Ierapetritou, R Ramachandran - International journal of …, 2012 - Elsevier
A novel manufacturing strategy based on continuous processing integrated with online
monitoring tools coupled with efficient automatic feedback control system is highly desired …

System-wide hybrid MPC–PID control of a continuous pharmaceutical tablet manufacturing process via direct compaction

R Singh, M Ierapetritou, R Ramachandran - European Journal of …, 2013 - Elsevier
The next generation of QbD based pharmaceutical products will be manufactured through
continuous processing. This will allow the integration of online/inline monitoring tools …

Implementation of an advanced hybrid MPC–PID control system using PAT tools into a direct compaction continuous pharmaceutical tablet manufacturing pilot plant

R Singh, A Sahay, KM Karry, F Muzzio… - International journal of …, 2014 - Elsevier
It is desirable for a pharmaceutical final dosage form to be manufactured through a quality
by design (QbD)-based approach rather than a quality by testing (QbT) approach. An …

A systematic framework for onsite design and implementation of a control system in a continuous tablet manufacturing process

R Singh, A Sahay, F Muzzio, M Ierapetritou… - Computers & chemical …, 2014 - Elsevier
A novel manufacturing strategy based on continuous processing integrated with
online/inline monitoring tools coupled with an advanced control system is highly desired for …

Recent progress in continuous and semi-continuous processing of solid oral dosage forms: a review

M Teżyk, B Milanowski, A Ernst… - Drug development and …, 2016 - Taylor & Francis
Context: Continuous processing is an innovative production concept well known and
successfully used in other industries for many years. The modern pharmaceutical industry is …

Multi-scale modeling of granulation processes: Bi-directional coupling of PBM with DEM via collision frequencies

D Barrasso, R Ramachandran - Chemical Engineering Research and …, 2015 - Elsevier
Wet granulation is a complex particle design process often operated inefficiently in industrial
applications. Enhanced process understanding is required to facilitate design, control, and …