Accumulating evidence supports the importance of redox signaling in the pathogenesis and
progression of hypertension. Redox signaling is implicated in many different physiological …

The smooth muscle cell is the sole cell type normally found in the media of mammalian
arteries. In the adult, it is a terminally differentiated cell that expresses cytoskeletal marker …

Abstract Objective Homocysteine (Hcy) is known as an independent risk factor for
atherosclerosis. C-reactive protein (CRP) directly participates in initiation and progression of …

Apoptosis or programmed cell death frequently parallels abnormalities in cell proliferation
and differentiation. As hypertrophy/hyperplasia or remodeling occurs in organs affected by …

The mechanism by which vascular smooth muscle (VSM) cells modulate their contractility in
response to structural cues from extracellular matrix remains poorly understood. When …

The previously reported association between hypertension and prostate cancer risk was
controversial. We performed this systematic review and meta-analysis of all available …

Essential hypertension is a complex multifactorial disease process that involves the
interaction of multiple genes at various loci throughout the genome, and the influence of …

Medial thickening of the pulmonary arterial wall, secondary to smooth muscle cell (SMC)
hyperplasia, is commonly observed in neonatal hypoxic pulmonary hypertension. Because …

Abnormalities in proliferative pathways have been noted in hypertension for over half a
century. They have been proposed by Folkow 1 to be a hallmark of hypertension, leading to …

T-cell function is also involved in the regulation of BP elevation and hypertensive
cardiovascular disease. Mice lacking the recombination-activating gene 1, which lack both T …