The medial frontal cortex and adjacent orbitofrontal cortex have been the focus of
investigations of decision-making, behavioral flexibility, and social behavior. We review …

The ventromedial prefrontal cortex (vmPFC) has been implicated in a variety of social,
cognitive, and affective functions that are commonly disrupted in mental illness. In this …

Rat orbitofrontal cortex (OFC) is located in the dorsal bank of the rhinal sulcus, and is
divided into the medial orbital area, ventral orbital area, ventrolateral orbital area, lateral …

Adaptive reward-related decision making requires accurate prospective consideration of the
specific outcome of each option and its current desirability. These mental simulations are …

One of the major functions of the orbitofrontal cortex (OFC) is to promote flexible motivated
behavior. It is no surprise, therefore, that recent work has demonstrated a prominent impact …

Adaptive reward-related decision making requires accurate prospective consideration of the
specific outcome of each option and its current desirability. Often this information must be …

The medial orbitofrontal cortex (mOFC) regulates a variety of cognitive functions, including
refining action selection involving reward uncertainty. This region sends projections to …

Forming and comparing subjective values (SVs) of choice options is a critical stage of
decision-making. Previous studies have highlighted a complex network of brain regions …

Background Major depressive disorder (MDD) is associated with dysfunction of the reward
system. As an important node in the reward system, the resting-state functional connectivity …

Background The orbitofrontal cortex (OFC) encodes internal representations of outcomes
and subjective value to facilitate flexible reward seeking. OFC activation is associated with …