Insights into mitoribosomal biogenesis from recent structural studies
The mitochondrial ribosome (mitoribosome) is a multicomponent machine that has unique
structural features. Biogenesis of the human mitoribosome includes correct maturation and …
structural features. Biogenesis of the human mitoribosome includes correct maturation and …
Central dogma rates in human mitochondria
E McShane, LS Churchman - Human Molecular Genetics, 2024 - academic.oup.com
In human cells, the nuclear and mitochondrial genomes engage in a complex interplay to
produce dual-encoded oxidative phosphorylation (OXPHOS) complexes. The coordination …
produce dual-encoded oxidative phosphorylation (OXPHOS) complexes. The coordination …
The human mitochondrial mRNA structurome reveals mechanisms of gene expression
The human mitochondrial genome encodes crucial oxidative phosphorylation system
proteins, pivotal for aerobic energy transduction. They are translated from nine …
proteins, pivotal for aerobic energy transduction. They are translated from nine …
Cytochrome c oxidase biogenesis – from translation to early assembly of the core subunit COX1
S Dennerlein, P Rehling, R Richter‐Dennerlein - FEBS letters, 2023 - Wiley Online Library
Mitochondria are the powerhouses of the cell as they produce the majority of ATP with their
oxidative phosphorylation (OXPHOS) machinery. The OXPHOS system is composed of the …
oxidative phosphorylation (OXPHOS) machinery. The OXPHOS system is composed of the …
Advances and opportunities in methods to study protein translation-A review
D Zhang, Y Gao, L Zhu, Y Wang, P Li - International Journal of Biological …, 2024 - Elsevier
It is generally believed that the regulation of gene expression involves protein translation
occurring before RNA transcription. Therefore, it is crucial to investigate protein translation …
occurring before RNA transcription. Therefore, it is crucial to investigate protein translation …
A kinetic dichotomy between mitochondrial and nuclear gene expression processes
Oxidative phosphorylation (OXPHOS) complexes, encoded by both mitochondrial and
nuclear DNA, are essential producers of cellular ATP, but how nuclear and mitochondrial …
nuclear DNA, are essential producers of cellular ATP, but how nuclear and mitochondrial …
Tetracyclines activate mitoribosome quality control and reduce ER stress to promote cell survival
Mitochondrial diseases are a group of disorders defined by defects in oxidative
phosphorylation caused by nuclear‐or mitochondrial‐encoded gene mutations. A main …
phosphorylation caused by nuclear‐or mitochondrial‐encoded gene mutations. A main …
Translation termination in human mitochondria–substrate specificity of mitochondrial release factors
F Nadler, R Richter-Dennerlein - Biological Chemistry, 2023 - degruyter.com
Mitochondria are the essential players in eukaryotic ATP production by oxidative
phosphorylation, which relies on the maintenance and accurate expression of the …
phosphorylation, which relies on the maintenance and accurate expression of the …
Unique architectural features of mammalian mitochondrial protein synthesis
Mitochondria rely on coordinated expression of their own mitochondrial DNA (mtDNA) with
that of the nuclear genome for their biogenesis. The bacterial ancestry of mitochondria has …
that of the nuclear genome for their biogenesis. The bacterial ancestry of mitochondria has …
Navigating the landscape of mitochondrial-ER communication in health and disease
CT Ronayne, P Latorre-Muro - Frontiers in Molecular Biosciences, 2024 - frontiersin.org
Intracellular organelle communication enables the maintenance of tissue homeostasis and
health through synchronized adaptive processes triggered by environmental cues …
health through synchronized adaptive processes triggered by environmental cues …