While metabolic reprogramming of cancer cells has long been considered from the
standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis …

Polyamines are essential for the proliferation, differentiation, and development of
eukaryotes. They include spermine, spermidine, and the diamine precursor putrescine, and …

Polyamines (ie, putrescine, spermidine, and spermine) are bioactive polycations capable of
binding nucleic acids and proteins and modulating signaling pathways. Polyamine functions …

Increased polyamine concentrations in the blood and urine of cancer patients reflect the
enhanced levels of polyamine synthesis in cancer tissues arising from increased activity of …

Correcting T-cell immunosuppression may unleash powerful antitumor responses; however,
knowledge about the mechanisms and modifiers that may be targeted to improve therapy …

The study of metabolism provides important information for understanding the biological
basis of cancer cells and the defects of cancer treatment. Disorders of polyamine …

Accumulating recent evidence indicates that the human microbiome plays essential roles in
pathophysiological states, including cancer. The tumor microbiome, an emerging concept …

Molecular carcinogenesis is a multistep process that involves acquired abnormalities in key
biological processes. The complexity of cancer pathogenesis is best illustrated in the six …

Spermidine, as a natural component from polyamine members, is originally isolated from
semen and also existed in many natural plants, and can be responsible for cell growth and …

Cancer cell metabolism differs significantly from the metabolism of non-transformed cells.
This altered metabolic reprogramming mediates changes in the uptake and use of nutrients …