Gene regulation in time and space during X-chromosome inactivation
A Loda, S Collombet, E Heard - Nature Reviews Molecular Cell Biology, 2022 - nature.com
X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …
Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer
H Chen, J Yao, R Bao, Y Dong, T Zhang, Y Du… - Molecular cancer, 2021 - Springer
Background The four major RNA adenosine modifications, ie, m 6 A, m 1 A, alternative
polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” …
polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” …
Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents
WO Castillo-Ordoñez, N Cajas-Salazar… - Neural regeneration …, 2024 - journals.lww.com
Alzheimer's disease is a progressive neurodegenerative disorder and the most common
cause of dementia that principally affects older adults. Pathogenic factors, such as oxidative …
cause of dementia that principally affects older adults. Pathogenic factors, such as oxidative …
DNA 5-methylcytosine detection and methylation phasing using PacBio circular consensus sequencing
Long single-molecular sequencing technologies, such as PacBio circular consensus
sequencing (CCS) and nanopore sequencing, are advantageous in detecting DNA 5 …
sequencing (CCS) and nanopore sequencing, are advantageous in detecting DNA 5 …
DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity
DNA replication timing and three-dimensional (3D) genome organization are associated
with distinct epigenome patterns across large domains. However, whether alterations in the …
with distinct epigenome patterns across large domains. However, whether alterations in the …
Megabase-scale methylation phasing using nanopore long reads and NanoMethPhase
The ability of nanopore sequencing to simultaneously detect modified nucleotides while
producing long reads makes it ideal for detecting and phasing allele-specific methylation …
producing long reads makes it ideal for detecting and phasing allele-specific methylation …
Genome-wide detection of imprinted differentially methylated regions using nanopore sequencing
Imprinting is a critical part of normal embryonic development in mammals, controlled by
defined parent-of-origin (PofO) differentially methylated regions (DMRs) known as imprinting …
defined parent-of-origin (PofO) differentially methylated regions (DMRs) known as imprinting …
Monoallelic expression can govern penetrance of inborn errors of immunity
Inborn errors of immunity (IEIs) are genetic disorders that underlie susceptibility to infection,
autoimmunity, autoinflammation, allergy and/or malignancy. Incomplete penetrance is …
autoimmunity, autoinflammation, allergy and/or malignancy. Incomplete penetrance is …
Association between MGMT Enhancer Methylation and MGMT Promoter Methylation, MGMT Protein Expression, and Overall Survival in Glioblastoma
K Zappe, K Pühringer, S Pflug, D Berger, A Böhm… - Cells, 2023 - mdpi.com
The repair protein O6-methylguanine-DNA methyltransferase (MGMT) is regulated
epigenetically, mainly by the methylation of the MGMT promoter. MGMT promoter …
epigenetically, mainly by the methylation of the MGMT promoter. MGMT promoter …
Modeling cross‐talk of RNA modification enzymes reveals tumor microenvironment‐associated clinical significance and immunotherapy prediction in hepatobiliary …
F Qi, J Li, Z Qi, B Zhou, B Yang, J Zhang, W Qin - MedComm, 2023 - Wiley Online Library
RNA modification includes four main types, N6‐methyladenosine, N1‐methyladenosine,
alternative polyadenylation (APA), and adenosine‐to‐inosine (A‐to‐I) RNA editing, involving …
alternative polyadenylation (APA), and adenosine‐to‐inosine (A‐to‐I) RNA editing, involving …