Therapeutic strategies to overcome taxane resistance in cancer
One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …
emergence of multidrug resistance (MDR). Numerous studies have been published …
Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance
K Natarajan, Y Xie, MR Baer, DD Ross - Biochemical pharmacology, 2012 - Elsevier
Since cloning of the ATP-binding cassette (ABC) family member breast cancer resistance
protein (BCRP/ABCG2) and its characterization as a multidrug resistance efflux transporter …
protein (BCRP/ABCG2) and its characterization as a multidrug resistance efflux transporter …
Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system
In this review we give an overview of the physiological functions of a group of ATP binding
cassette (ABC) transporter proteins, which were discovered, and still referred to, as …
cassette (ABC) transporter proteins, which were discovered, and still referred to, as …
ABCG2: determining its relevance in clinical drug resistance
RW Robey, O Polgar, J Deeken, KW To… - Cancer and Metastasis …, 2007 - Springer
Multidrug resistance is a major obstacle to successful cancer treatment. One mechanism by
which cells can become resistant to chemotherapy is the expression of ABC transporters that …
which cells can become resistant to chemotherapy is the expression of ABC transporters that …
Chemotherapy-induced resistance by ATP-binding cassette transporter genes
A key issue in the treatment of many cancers is the development of resistance to
chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them …
chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them …
Human ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics
K Noguchi, K Katayama, Y Sugimoto - … and personalized medicine, 2014 - Taylor & Francis
Adenine triphosphate (ATP)-binding cassette (ABC) transporter proteins, such as ABCB1/P-
glycoprotein (P-gp) and ABCG2/breast cancer resistance protein (BCRP), transport various …
glycoprotein (P-gp) and ABCG2/breast cancer resistance protein (BCRP), transport various …
The controversial role of ABC transporters in clinical oncology
The phenomenon of multidrug resistance in cancer is often associated with the
overexpression of the ABC (ATP-binding cassette) transporters Pgp (P …
overexpression of the ABC (ATP-binding cassette) transporters Pgp (P …
Role of ABCG2/BCRP in biology and medicine
P Krishnamurthy, JD Schuetz - Annu. Rev. Pharmacol. Toxicol., 2006 - annualreviews.org
▪ Abstract The protein variously named ABCG2/BCRP/MXR/ABCP is a recently described
ATP-binding cassette (ABC) transporter originally identified by its ability to confer drug …
ATP-binding cassette (ABC) transporter originally identified by its ability to confer drug …
Drug resistance mechanisms of acute myeloid leukemia stem cells
J Niu, D Peng, L Liu - Frontiers in Oncology, 2022 - frontiersin.org
Acute myeloid leukemia (AML) is a polyclonal and heterogeneous hematological
malignancy. Relapse and refractory after induction chemotherapy are still challenges for …
malignancy. Relapse and refractory after induction chemotherapy are still challenges for …
Molecular pharmacology of ABCG2 and its role in chemoresistance
AE Stacy, PJ Jansson, DR Richardson - Molecular pharmacology, 2013 - ASPET
The ATP-binding cassette, subfamily G, isoform 2 protein (ABCG2) is an important member
of the ABC transporter superfamily, which has been suggested to be involved in multidrug …
of the ABC transporter superfamily, which has been suggested to be involved in multidrug …