Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
PPAR-α modulators as current and potential cancer treatments
Y Tan, M Wang, K Yang, T Chi, Z Liao, P Wei - Frontiers in oncology, 2021 - frontiersin.org
Cancer is one of the leading causes of mortality worldwide. PPAR modulators may hold
great potential for the management of cancer patients. Indeed, PPARs are critical sensors …
great potential for the management of cancer patients. Indeed, PPARs are critical sensors …
RUNX2 recruits the NuRD (MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis
X Yin, X Teng, T Ma, T Yang, J Zhang, M Huo… - Cell Death & …, 2022 - nature.com
Runt-related transcription factor 2 (RUNX2) is an osteogenesis-related transcription factor
that has emerged as a prominent transcription repressing factor in carcinogenesis. However …
that has emerged as a prominent transcription repressing factor in carcinogenesis. However …
PPARs and angiogenesis—Implications in pathology
N Wagner, KD Wagner - International Journal of Molecular Sciences, 2020 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) belong to the family of ligand-activated
nuclear receptors. The PPAR family consists of three subtypes encoded by three separate …
nuclear receptors. The PPAR family consists of three subtypes encoded by three separate …
[HTML][HTML] Peroxisome proliferator-activated receptors (PPARs) are potential drug targets for cancer therapy
Q Gou, X Gong, J Jin, J Shi, Y Hou - Oncotarget, 2017 - ncbi.nlm.nih.gov
Peroxisome-proliferator-activated receptors (PPARs) are nuclear hormone receptors
including PPARα, PPARδ and PPARγ, which play an important role in regulating cancer cell …
including PPARα, PPARδ and PPARγ, which play an important role in regulating cancer cell …
Downregulation of the circadian rhythm regulator HLF promotes multiple-organ distant metastases in non-small cell lung cancer through PPAR/NF-κb signaling
J Chen, A Liu, Z Lin, B Wang, X Chai, S Chen, W Lu… - Cancer Letters, 2020 - Elsevier
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death due to its
early recurrence and widespread metastatic potential. Accumulating studies have reported …
early recurrence and widespread metastatic potential. Accumulating studies have reported …
Peroxisome proliferator-activated receptors and the hallmarks of cancer
N Wagner, KD Wagner - Cells, 2022 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) function as nuclear transcription factors
upon the binding of physiological or pharmacological ligands and heterodimerization with …
upon the binding of physiological or pharmacological ligands and heterodimerization with …
Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis
G Zhang, D Panigrahy, SH Hwang… - Proceedings of the …, 2014 - National Acad Sciences
Prostaglandins derived from the cyclooxygenase (COX) pathway and epoxyeicosatrienoic
acids (EETs) from the cytochrome P450/soluble epoxide hydrolase (sEH) pathway are …
acids (EETs) from the cytochrome P450/soluble epoxide hydrolase (sEH) pathway are …
Fenofibrate inhibited pancreatic cancer cells proliferation via activation of p53 mediated by upregulation of LncRNA MEG3
D Hu, C Su, M Jiang, Y Shen, A Shi, F Zhao… - Biochemical and …, 2016 - Elsevier
There is still no suitable drug for pancreatic cancer treatment, which is one of the most
aggressive human tumors. Maternally expressed gene 3 (MEG3), a LncRNA, has been …
aggressive human tumors. Maternally expressed gene 3 (MEG3), a LncRNA, has been …
Cytochrome P450-derived fatty acid epoxides and diols in angiogenesis and stem cell biology
T Frömel, Z Naeem, L Pirzeh, I Fleming - Pharmacology & Therapeutics, 2022 - Elsevier
Cytochrome P450 (CYP) enzymes are frequently referred to as the third pathway for the
metabolism of arachidonic acid. While it is true that these enzymes generate arachidonic …
metabolism of arachidonic acid. While it is true that these enzymes generate arachidonic …