The neurobiology of zinc in health and disease

CJ Frederickson, JY Koh, AI Bush - Nature Reviews Neuroscience, 2005 - nature.com
The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC (for
example, the Smith Papyrus), and zinc has apparently been used fairly steadily throughout …

Molecular structure and function of the glycine receptor chloride channel

JW Lynch - Physiological reviews, 2004 - journals.physiology.org
The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

Synaptically released zinc: physiological functions and pathological effects

CJ Frederickson, AI Bush - Biometals, 2001 - Springer
In addition to its familiar role as a component of metalloproteins, zinc is also sequestered in
the presynaptic vesicles of a specialized type of neurons calledzinc-containing'neurons …

Brain, aging and neurodegeneration: role of zinc ion availability

E Mocchegiani, C Bertoni-Freddari, F Marcellini… - Progress in …, 2005 - Elsevier
Actual fields of research in neurobiology are not only aimed at understanding the different
aspects of brain aging but also at developing strategies useful to preserve brain …

Zn2+ ions: modulators of excitatory and inhibitory synaptic activity

TG Smart, AM Hosie, PS Miller - The Neuroscientist, 2004 - journals.sagepub.com
The role of Zn2+ in the CNS has remained enigmatic for several decades. This divalent
cation is accumulated by specific neurons into synaptic vesicles and can be released by …

Zinc and cortical plasticity

AS Nakashima, RH Dyck - Brain research reviews, 2009 - Elsevier
The divalent cation zinc is an essential element, having both universal and specified
functions throughout the body. In the mammalian telencephalon, zinc has extensive effects …

Zinc as a neuromodulator in the central nervous system with a focus on the olfactory bulb

LJ Blakemore, PQ Trombley - Frontiers in cellular neuroscience, 2017 - frontiersin.org
The olfactory bulb (OB) is central to the sense of smell, as it is the site of the first synaptic
relay involved in the processing of odor information. Odor sensations are first transduced by …

A genetically encoded far-red fluorescent indicator for imaging synaptically released Zn2+

T Wu, M Kumar, J Zhang, S Zhao, M Drobizhev… - Science …, 2023 - science.org
Synaptic zinc ion (Zn2+) has emerged as a key neuromodulator in the brain. However, the
lack of research tools for directly tracking synaptic Zn2+ in the brain of awake animals …

Structure and pharmacologic modulation of inhibitory glycine receptors

CF Burgos, GE Yévenes, LG Aguayo - Molecular pharmacology, 2016 - ASPET
Glycine receptors (GlyR) are inhibitory Cys-loop ion channels that contribute to the control of
excitability along the central nervous system (CNS). GlyR are found in the spinal cord and …

Molecular pharmacology of the glycine receptor chloride channel

TI Webb, JW Lynch - Current pharmaceutical design, 2007 - ingentaconnect.com
The glycine receptor (GlyR) Cl-channel belongs to the cysteine-loop family of ligand-gated
ion channel receptors. It is best known for mediating inhibitory neurotransmission in motor …