The central role of DNA damage in the ageing process
B Schumacher, J Pothof, J Vijg, JHJ Hoeijmakers - Nature, 2021 - nature.com
Ageing is a complex, multifaceted process leading to widespread functional decline that
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …
Cellular functions of the protein kinase ATM and their relevance to human disease
The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
A Ray Chaudhuri, A Nussenzweig - Nature reviews Molecular cell …, 2017 - nature.com
Cells are exposed to various endogenous and exogenous insults that induce DNA damage,
which, if unrepaired, impairs genome integrity and leads to the development of various …
which, if unrepaired, impairs genome integrity and leads to the development of various …
DNA single-strand break repair and human genetic disease
KW Caldecott - Trends in cell biology, 2022 - cell.com
DNA single-strand breaks (SSBs) are amongst the commonest DNA lesions arising in cells,
with many tens of thousands induced in each cell each day. SSBs arise not only from …
with many tens of thousands induced in each cell each day. SSBs arise not only from …
Neuronal enhancers are hotspots for DNA single-strand break repair
Defects in DNA repair frequently lead to neurodevelopmental and neurodegenerative
diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic …
diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic …
[HTML][HTML] The importance of poly (ADP-ribose) polymerase as a sensor of unligated Okazaki fragments during DNA replication
H Hanzlikova, I Kalasova, AA Demin, LE Pennicott… - Molecular cell, 2018 - cell.com
Poly (ADP-ribose) is synthesized by PARP enzymes during the repair of stochastic DNA
breaks. Surprisingly, however, we show that most if not all endogenous poly (ADP-ribose) is …
breaks. Surprisingly, however, we show that most if not all endogenous poly (ADP-ribose) is …
A unified model for the G1/S cell cycle transition
Efficient S phase entry is essential for development, tissue repair, and immune defences.
However, hyperactive or expedited S phase entry causes replication stress, DNA damage …
However, hyperactive or expedited S phase entry causes replication stress, DNA damage …
Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease
G Welch, LH Tsai - EMBO reports, 2022 - embopress.org
Neurons are highly susceptible to DNA damage accumulation due to their large energy
requirements, elevated transcriptional activity, and long lifespan. While newer research has …
requirements, elevated transcriptional activity, and long lifespan. While newer research has …
DNA damage responses and p53 in the aging process
HL Ou, B Schumacher - Blood, The Journal of the American …, 2018 - ashpublications.org
The genome is constantly attacked by genotoxic insults. DNA damage has long been
established as a cause of cancer development through its mutagenic consequences …
established as a cause of cancer development through its mutagenic consequences …
XRCC1 prevents toxic PARP1 trapping during DNA base excision repair
AA Demin, K Hirota, M Tsuda, M Adamowicz… - Molecular cell, 2021 - cell.com
Mammalian DNA base excision repair (BER) is accelerated by poly (ADP-ribose)
polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect …
polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect …