Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …

Chromatin consists of a complex of DNA and histone proteins as its core components and
plays an important role in both packaging DNA and regulating DNA metabolic pathways …

The centromere performs a universally conserved function, to accurately partition genetic
information upon cell division. Yet, centromeres are among the most rapidly evolving …

Kinetochores are multisubunit complexes that assemble on centromeres to bind spindle
microtubules and promote faithful chromosome segregation during cell division. A 16 …

During mitosis, the macromolecular kinetochore complex assembles on the centromere to
orchestrate chromosome segregation. The properties and architecture of the 16-subunit …

The chromosomal loci known as centromeres (CEN) mediate the equal distribution of the
duplicated genome between both daughter cells. Specifically, centromeres recruit a protein …

Eukaryotic chromosome segregation relies upon specific connections from DNA to the
microtubule-based spindle that forms at cell division. The chromosomal locus that directs …

Highlights•Kinetochores, large macromolecular assemblies, link chromosome to spindle
microtubules.•Kinetochores are crucially required for accurate chromosome segregation in …

Centromeric chromatin undergoes major changes in composition and architecture during
each cell cycle. These changes in specialized chromatin facilitate kinetochore formation in …