Microbial secondary metabolites are pivotal for the development of novel drugs. However,
conventional culture techniques, have left a vast array of unexpressed biosynthetic gene …

Natural products with antibacterial activity are highly desired globally to combat against
multidrug-resistant (MDR) bacteria. Antibacterial peptide (ABP), especially cyclic ABP …

Macrocyclization of peptides reduces conformational flexibilities, potentially leading to
improved drug-like properties, such as target specificities and metabolic stabilities. As …

Current needs in finding new antibiotics against emerging multidrug-resistant superbugs are
pushing the scientific community into coming back to Nature for the discovery of novel active …

Penicillin-binding protein-type thioesterases (PBP-type TEs) are a recently identified group
of peptide cyclases that catalyze head-to-tail macrolactamization of nonribosomal peptides …

Whole-genome sequencing and bioinformatics analyses have shown that the potential of
synthesizing secondary metabolites from marine-derived Streptomyces has been …

The strain Streptomyces cacaoi CA-170360 produces the cyclic pentapeptides
pentaminomycins A–H and BE-18257 A–C, two families of cyclopeptides synthesized by two …

Lignin is an underutilized sustainable source of aromatic compounds. To valorize the low-
value lignin monomers, we proposed an efficient strategy, involving enzymatic conversion …

The emergence of antibiotic resistant pathogenic strains, especially Gram-negative bacteria,
has seriously increased in the last decades, endangering the efficiency of the antibiotics …

The strain Streptomyces cacaoi CA-170360 produces the cyclic pentapeptides
pentaminomycins AE and BE-18257 AC, two families of cyclopeptides synthesized by two …