Neurotensin in reward processes

ML Torruella-Suárez, ZA McElligott - Neuropharmacology, 2020 - Elsevier
Neurotensin (NTS) is a neuropeptide neurotransmitter expressed in the central and
peripheral nervous systems. Many studies over the years have revealed a number of roles …

Dissecting the roles of GABA and neuropeptides from rat central amygdala CRF neurons in anxiety and fear learning

MB Pomrenze, SM Giovanetti, R Maiya, AG Gordon… - Cell reports, 2019 - cell.com
Central amygdala (CeA) neurons that produce corticotropin-releasing factor (CRF) regulate
anxiety and fear learning. These CeA CRF neurons release GABA and several …

Neurotensin and Neurotensin Receptors in Stress-related Disorders: Pathophysiology & Novel Drug Targets

G Kyriatzis, M Khrestchatisky, L Ferhat… - Current …, 2024 - ingentaconnect.com
Neurotensin (NT) is a 13-amino acid neuropeptide widely distributed in the CNS that has
been involved in the pathophysiology of many neural and psychiatric disorders. There are …

Adolescent alcohol exposure produces sex differences in negative affect-like behavior and group I mGluR BNST plasticity

CR Kasten, KL Carzoli, NM Sharfman… - …, 2020 - nature.com
Adolescent alcohol exposure increases the risk of developing alcohol use disorders (AUDs),
yet the mechanisms responsible for this vulnerability remain largely unknown. One potential …

Maternal separation enhances conditioned fear and decreases the mRNA levels of the neurotensin receptor 1 gene with hypermethylation of this gene in the rat …

H Toda, S Boku, S Nakagawa, T Inoue, A Kato… - PloS one, 2014 - journals.plos.org
Stress during postnatal development is associated with an increased risk for depression,
anxiety disorders, and substance abuse later in life, almost as if mental illness is able to be …

Genome-wide scan of dental fear and anxiety nominates novel genes

Y Zhou, DW McNeil, S Haworth… - Journal of Dental …, 2022 - journals.sagepub.com
Dental care–related fear and anxiety (DFA) is prevalent, affects oral health care utilization,
and is related to poor oral health and decreased quality of life. In addition to learned and …

Neurotensin receptor 1 deletion decreases methamphetamine self‐administration and the associated reduction in dopamine cell firing

S Dominguez‐Lopez, R Sharma… - Addiction …, 2021 - Wiley Online Library
We previously reported that a non‐selective pharmacological blockade of neurotensin
receptors in the ventral tegmental area (VTA) decreases methamphetamine (METH) self …

Increased brain neurotensin and NTSR2 lead to weak nociception in NTSR3/Sortilin knockout mice

C Devader, S Moreno, M Roulot, E Deval… - Frontiers in …, 2016 - frontiersin.org
The neuropeptide neurotensin (NT) elicits numerous pharmacological effects through three
different receptors (NTSR1, NTSR2, and NTSR3 also called sortilin). Pharmacological …

Potential roles of neurotensin on cognition in conditions of obese-insulin resistance

N Saiyasit, J Sripetchwandee, N Chattipakorn… - Neuropeptides, 2018 - Elsevier
Neurotensin is an endogenous tridecapeptide that can be found in both central and
peripheral nervous systems. Under normal physiological conditions, neurotensin is involved …

Distinct genetic signatures of cortical and subcortical regions associated with human memory

PK Tan, E Ananyev, PJ Hsieh - Eneuro, 2019 - eneuro.org
Despite the discovery of gene variants linked to memory performance, understanding the
genetic basis of adult human memory remains a challenge. Here, we devised an …