Neonates have little immunological memory and a developing immune system, which
increases their vulnerability to infectious agents. Recent advances in the understanding of …

Respiratory syncytial virus (RSV) is an exceptional mucosal pathogen. It specializes in
infection of the ciliated respiratory epithelium, causing disease of variable severity with little …

The ability to decode antigen specificities encapsulated in the sequences of rearranged T-
cell receptor (TCR) genes is critical for our understanding of the adaptive immune system …

Recent advances in technology have led to the realization that the populations of naive T
cells specific for different foreign peptide: MHC (p: MHC) ligands vary in size. This variability …

Neonatal CD4+ and CD8+ T cells have historically been characterized as immature or
defective. However, recent studies prompt a reinterpretation of the functions of neonatal T …

Respiratory Syncytial Virus (RSV) is the commonest cause of severe respiratory infection in
infants, leading to over 3 million hospitalizations and around 66,000 deaths worldwide each …

Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract
disease in children< 2 years of age. Increased morbidity and mortality have been reported in …

Although largely deprived from exogenous stimuli in utero, the mucosal barriers of the
neonate after birth are bombarded by environmental, nutritional, and microbial exposures …

The cytometric enumeration and characterization of antigen‐specific lymphocytes, as
introduced about 15 years ago, has contributed significantly to our understanding of …

Naive CD8+ T cells give rise to cytotoxic T lymphocytes (CTLs), which promote the effective
eradication of viruses and tumours. Although the past decades have seen enormous …