Evolution of strategies to improve preclinical cardiac safety testing
G Gintant, PT Sager, N Stockbridge - Nature reviews Drug discovery, 2016 - nature.com
The early and efficient assessment of cardiac safety liabilities is essential to confidently
advance novel drug candidates. This article discusses evolving mechanistically based …
advance novel drug candidates. This article discusses evolving mechanistically based …
Bioengineering approaches to treat the failing heart: from cell biology to 3D printing
Successfully engineering a functional, human, myocardial pump would represent a
therapeutic alternative for the millions of patients with end-stage heart disease and provide …
therapeutic alternative for the millions of patients with end-stage heart disease and provide …
Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing
Biomedical research has relied on animal studies and conventional cell cultures for
decades. Recently, microphysiological systems (MPS), also known as organs-on-chips, that …
decades. Recently, microphysiological systems (MPS), also known as organs-on-chips, that …
Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness
Single cardiomyocytes contain myofibrils that harbor the sarcomere-based contractile
machinery of the myocardium. Cardiomyocytes differentiated from human pluripotent stem …
machinery of the myocardium. Cardiomyocytes differentiated from human pluripotent stem …
Muscle tissue engineering in fibrous gelatin: implications for meat analogs
Bioprocessing applications that derive meat products from animal cell cultures require food-
safe culture substrates that support volumetric expansion and maturation of adherent muscle …
safe culture substrates that support volumetric expansion and maturation of adherent muscle …
Cellular and engineered organoids for cardiovascular models
An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
Use of human induced pluripotent stem cell–derived cardiomyocytes in preclinical cancer drug cardiotoxicity testing: a scientific statement from the American Heart …
It is now well recognized that many lifesaving oncology drugs may adversely affect the heart
and cardiovascular system, including causing irreversible cardiac injury that can result in …
and cardiovascular system, including causing irreversible cardiac injury that can result in …
Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues
Defining the chronic cardiotoxic effects of drugs during preclinical screening is hindered by
the relatively short lifetime of functional cardiac tissues in vitro, which are traditionally …
the relatively short lifetime of functional cardiac tissues in vitro, which are traditionally …
[HTML][HTML] Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes
FB Bedada, M Wheelwright, JM Metzger - Biochimica et Biophysica Acta …, 2016 - Elsevier
Human heart failure due to myocardial infarction is a major health concern. The paucity of
organs for transplantation limits curative approaches for the diseased and failing adult heart …
organs for transplantation limits curative approaches for the diseased and failing adult heart …
Engineered heart tissues and induced pluripotent stem cells: macro-and microstructures for disease modeling, drug screening, and translational studies
Engineered heart tissue has emerged as a personalized platform for drug screening. With
the advent of induced pluripotent stem cell (iPSC) technology, patient-specific stem cells can …
the advent of induced pluripotent stem cell (iPSC) technology, patient-specific stem cells can …