The T-box family of transcription factors exhibits widespread involvement throughout
development in all metazoans. T-box proteins are characterized by a DNA-binding motif …

The Notch pathway is a crucial cell-fate regulator in the developing heart. Attention in the
past centered on Notch function in cardiomyocytes. However, recent advances demonstrate …

Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …

Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in
young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1. 5 …

Transcription factors (TFs) are thought to function with partners to achieve specificity and
precise quantitative outputs. In the developing heart, heterotypic TF interactions, such as …

The spinal cord and mesodermal tissues of the trunk such as the vertebral column and
skeletal musculature derive from neuro-mesodermal progenitors (NMPs). Sox2, Brachyury …

Rationale: Cardiac fibroblasts are critical to proper heart function through multiple
interactions with the myocardial compartment, but appreciation of their contribution has …

Over 500 genetic loci have been associated with risk of cardiovascular diseases (CVDs);
however, most loci are located in gene-distal non-coding regions and their target genes are …

High throughput sequencing technologies have become essential in studies on genomics,
epigenomics, and transcriptomics. Although sequencing information has traditionally been …

Background: There is increasing need for better therapies to prevent the development of
heart failure after myocardial infarction (MI). An injectable hydrogel derived from …